LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Strontium ranelate inhibits wear particle-induced aseptic loosening in mice

Geng, Tianxiang; Sun, Shouxuan; Yu, Haochen; Guo, Haohui; Zheng, Mengxue; Zhang, Shuai; Chen, Xi; Jin, Qunhua.

Braz. j. med. biol. res; 51 (9), 2018

The imbalance between bone formation and osteolysis plays a key role in the pathogenesis of aseptic loosening. Strontium ranelate (SR) can promote bone formation and inhibit osteolysis. The aim of this study was to explore the role and mechanism of SR in aseptic loosening induced by wear particles. Twent...

Miembros Artificiales, Fenómenos Biomecánicos, Western Blotting, Resorción Ósea/tratamiento farmacológico, Ensayo de Inmunoadsorción Enzimática, Extremidad Inferior/cirugía, Ratones Endogámicos C57BL, Osteólisis/tratamiento farmacológico, Implantación de Prótesis, Tiofenos/farmacología

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Lesión osteolítica de calota por sífilis secundaria

Bone involvement of syphilis can be observed in tertiary and congenital syphilis. It is infrequent during the secondary stage. The skull is the most affected bone in secondary syphilis, and its most frequent form of presentation is proliferative osteitis. If the skull is affected, headache is usual and c...