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LncRNA SNHG7/miR-34a-5p/SYVN1 axis plays a vital role in proliferation, apoptosis and autophagy in osteoarthritis

Tian, Feng; Wang, Junhu; Zhang, Zhanhua; Yang, Jie.
Biol. Res; 53 (), 2020
BACKGROUND: Osteoarthritis (OA) is one of the most common rheumatic diseases of which clinical symptoms includes swelling, synovitis and inflammatory pain, affect patients' daily life. It was reported that non-coding RNAs play vital roles in OA. However, the regulation mechanism of ncRNA in OA pathogenes...
Apoptosis/fisiología, Autofagia/fisiología, MicroARNs/metabolismo, Osteoartritis/metabolismo, ARN Largo no Codificante/metabolismo, Ubiquitina-Proteína Ligasas/metabolismo, Apoptosis/genética, Autofagia/genética, MicroARNs/genética, Osteoartritis/genética, ARN Largo no Codificante/genética, Ubiquitina-Proteína Ligasas/genética, Western Blotting, Proliferación Celular, Regulación hacia Abajo, Ensayo de Inmunoadsorción Enzimática, Reacción en Cadena en Tiempo Real de la Polimerasa, Regulación hacia Arriba
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Involvement of TLR4 in the protective effect of intra-articular administration of curcumin on rat experimental osteoarthritis

Yan, Dan; He, Bingshu; Guo, Jie; Li, Shulan; Wang, Jun.
Acta cir. bras; 34 (6), 2019
Abstract Purpose In view of the principal role of Toll-like receptor 4 (TLR4) in mediating sterile inflammatory response contributing to osteoarthritis (OA) pathogenesis, we used lipopolysaccharide (LPS), a known TLR4 activator, to clarify whether modulation of TLR4 contributed to the protective action...
Ligamento Cruzado Anterior/patología, Ligamento Cruzado Anterior/cirugía, Western Blotting, Curcumina/farmacología, Modelos Animales de Enfermedad, Ensayo de Inmunoadsorción Enzimática, Inyecciones Intraarteriales, Interleucina-1beta/metabolismo, Lipopolisacáridos, FN-kappa B/metabolismo, Osteoartritis/inducido químicamente, Osteoartritis/metabolismo, Osteoartritis/prevención & control, Reacción en Cadena de la Polimerasa, Receptor Toll-Like 4/efectos de los fármacos, Receptor Toll-Like 4/metabolismo, Linfotoxina-alfa/metabolismo
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The effects of chitosan oligosaccharides on OPG and RANKL expression in a rat osteoarthritis model

Zhang, Chun; Liao, Qi; Ming, Jiang-Hua; Hu, Ge-Liang; Chen, Qing; Liu, Shi-Qing; Li, Ya-Ming.
Acta cir. bras; 32 (6), 2017
Abstract Purpose: To investigate the effect of chitosan oligosaccharides (COS) against osteoarthritis (OA) and preliminarily discuss the osteoprotegerin (OPG), receptor activator of NF-κB ligand (RANKL) and RANK expression in a rat OA model. Methods: Thirty-six 6-week-old Male SD rats were randoml...
Cartílago Articular/efectos de los fármacos, Cartílago Articular/metabolismo, Quitosano/farmacología, Modelos Animales de Enfermedad, Regulación de la Expresión Génica, Oligosacáridos/farmacología, Osteoartritis/metabolismo, Osteoprotegerina/efectos de los fármacos, Osteoprotegerina/metabolismo, Ligando RANK/metabolismo, Ratas Sprague-Dawley
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Role of HIF-1α signaling pathway in osteoarthritis: A systematic review

Fernández-Torres, Javier; Martínez-Nava, Gabriela Angélica; Gutiérrez-Ruíz, María Concepción; Gómez-Quiroz, Luis Enrique; Gutiérrez, Marwin.
Rev. bras. reumatol; 57 (2), 2017
Abstract Osteoarthritis (OA) is the most common form of arthritis and is frequently diagnosed and managed in primary care; it is characterized by loss of articular hyaline cartilage, which is a unique connective tissue that physiologically lacks blood vessels. Articular cartilage survives in a microenvir...
Cartílago Articular/metabolismo, Cartílago Articular/patología, Regulación de la Expresión Génica, Factor 1 Inducible por Hipoxia/fisiología, Osteoartritis/metabolismo, Osteoartritis/fisiopatología, Transducción de Señal
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