Development of a rat model of knee osteoarthritis by a combination of monoiodoacetate and streptozotocin
Int. j. morphol; 35 (4), 2017
SUMMARY: Osteoarthritis (OA) caused by ageing joints or as a secondary complication of diabetes is a common health problem. We sought to develop an animal model of OA induced by a combination of the chondrocyte glycolytic inhibitor mono-iodoacetate (MIA) and streptozotocin (STZ), the agent that induces d...
Modelos Animales de Enfermedad, Osteoartritis de la Rodilla/inducido químicamente, Osteoartritis de la Rodilla/patología, Ácido Yodoacético/toxicidad, Estreptozocina/toxicidad, Combinación de Medicamentos, Cartílago Articular/patología, Cartílago Articular/ultraestructura, Ratas Sprague-Dawley, Microscopía Electrónica, Diabetes Mellitus Experimental, Cartílago Articular/efectos de los fármacos