SUMMARY: Senile osteoporosis is mainly caused by reduced osteoblast differentiation and has become the leading cause of fractures in the elderly worldwide. Natural organics are emerging as a potential option for the prevention and treatment of osteoporosis. This study was designed to study the effect of ...
Resveratrol/administración & dosificación,
Resveratrol/farmacología,
Osteoporosis/tratamiento farmacológico,
Diferenciación Celular/efectos de los fármacos,
Células Madre Mesenquimatosas/efectos de los fármacos,
Células Madre Mesenquimatosas/citología,
Sirtuina 1,
Modelos Animales de Enfermedad,
Western Blotting,
Ratones Endogámicos C57BL,
Osteogénesis/efectos de los fármacos
Abstract In order to better understand the ossification processes in anurans our study was carried out on tadpoles and adults of Lithobates catesbeianus. In this sense, we characterized the kinetic properties of alkaline phosphatase with p-nitrophenylphosphatase (pNPP) and pyrophosphate (PPi) and evaluat...
BACKGROUND: Fibrous scars frequently form at the sites of bone nonunion when attempts to repair bone fractures have failed. However, the detailed mechanism by which fibroblasts, which are the main components of fibrous scars, impede osteogenesis remains largely unknown. RESULTS: In this study, we found t...
SUMMARY: Traumatized bone tissue has the capacity to repair itself so that it eventually regains its almost original form, even in the case of artificially inserted implants. The process that stays at the base of the regeneration is represented by osteogenesis or remote osteogenesis. The major difference...
El presente trabajo muestra la obtención de un material a partir de un polímero sintético (TerP) y otro natural, mediante entrecruzamiento físico y su caracterización fisicoquímica y biológica, con el fin de emplearlos para regeneración de tejido óseo. Las membranas fueron obtenidas por l...
Cromatografía en Gel,
Diferenciación Celular,
Ensayo de Materiales,
Espectroscopía Infrarroja por Transformada de Fourier,
Huesos/química,
Materiales Biocompatibles/síntesis química,
Materiales Biocompatibles/toxicidad,
Osteogénesis,
Polímeros/química,
Polímeros/toxicidad,
Quitosano/química,
Quitosano/toxicidad,
Regeneración Ósea,
Resonancia Magnética Nuclear Biomolecular,
Técnicas de Cultivo de Célula
MicroRNAs (miRNAs) are small non-coding RNA molecules that play critical roles in post-transcriptional gene regulation. They function by binding to target messenger RNA (mRNA) molecules, leading to their degradation or inhibiting their translation i...
SUMMARY: The Masquelet technique or membrane induction is considered new in many ways, born under the need to seek therapeutic options in patients with extensive bone lesions.
Since this technique was proposed, hopeful and reproducible results have been reported to different centers throughout the world....
Anjos, Igor Domingos dos;
Nogueira, Vinícius Otávio;
Taranto, Martinelle Ferreira da Rocha;
Ramazzotto, Lucas Alexandre;
Nelson-Filho, Paulo;
Küchler, Erika Calvano;
Menezes-Oliveira, Maria Angélica Hueb de;
Lepri, César Penazzo;
Baratto-Filho, Flares;
Madalena, Isabela Ribeiro.
Objetivo: Evidências científicas sugerem que a deficiência de estrógeno e fatores genéticos influenciam o desenvolvimento do sistema estomatognático. Este estudo teve como objetivo avaliar a influência da deficiência de estrógeno na expressão gênica de TNF-α, IL-1β, IL-6 e IL-10 durante o de...
Purpose: The aim of this study was to evaluate the effect of platelet-rich fibrin (PRF) and autograft on non-critical bone repair. Methods: Four bone defects (8.3 × 2 mm) were produced on the calvarium of 15 rabbits. The surgical defects were treated with either autograft, autograft associated to PRF, P...
Abstract Mesenchymal stem cells (MSCs) have great potential for application in cell therapy and tissue engineering procedures because of their plasticity and capacity to differentiate into different cell types. Given the widespread use of MSCs, it is necessary to better understand some properties related...
