LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

MicroRNA-629-5p promotes osteosarcoma proliferation and migration by targeting caveolin 1

Gao, Chunsheng; Gao, Jun; Zeng, Ge; Yan, Huichao; Zheng, Junhua; Guo, Weichun.

Braz. j. med. biol. res; 54 (6), 2021

Osteosarcoma is a highly malignant tumor that occurs in the bone. Previous studies have shown that multiple microRNAs (miRNAs) regulate the development of osteosarcoma. This study aimed to explore the role of miR-629-5p and its target gene, caveolin 1 (CAV1), in osteosarcoma development. To analyze the e...

Neoplasias Óseas/genética, Caveolina 1/genética, Línea Celular Tumoral, Movimiento Celular/genética, Proliferación Celular/genética, Regulación Neoplásica de la Expresión Génica, MicroARNs/genética, Osteosarcoma/genética

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Down-regulation of HCP5 inhibits cell proliferation, migration, and invasion through regulating EPHA7 by competitively binding miR-101 in osteosarcoma

Tu, Yangmao; Cai, Qing; Zhu, Xuemei; Xu, Min.

Braz. j. med. biol. res; 54 (2), 2021

Patients with osteosarcoma (OS) usually have poor overall survival because of frequent metastasis. Long non-coding RNAs (lncRNAs) have been reported to be associated with tumorigenesis and metastasis. In this study, we investigated the expression and roles of lncRNA human histocompatibility leukocyte ant...

Neoplasias Óseas/genética, Neoplasias Óseas/patología, Línea Celular Tumoral, Movimiento Celular, Proliferación Celular, Regulación hacia Abajo, Regulación Neoplásica de la Expresión Génica, MicroARNs/metabolismo, Invasividad Neoplásica, Osteosarcoma/genética, Osteosarcoma/patología, ARN Largo no Codificante/genética, Receptor EphA7/metabolismo

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Investigating ego modules and pathways in osteosarcoma by integrating the EgoNet algorithm and pathway analysis

Chen, XY; Chen, YH; Zhang, LJ; Wang, Y; Tong, ZC.

Braz. j. med. biol. res; 50 (2), 2017

Osteosarcoma (OS) is the most common primary bone malignancy, but current therapies are far from effective for all patients. A better understanding of the pathological mechanism of OS may help to achieve new treatments for this tumor. Hence, the objective of this study was to investigate ego modules and ...

Algoritmos, Neoplasias Óseas/genética, Perfilación de la Expresión Génica, Regulación Neoplásica de la Expresión Génica/genética, Redes Reguladoras de Genes/genética, Osteosarcoma/genética, Mapas de Interacción de Proteínas/genética

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