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Role of ACE and ACE-2 in abrogated cardioprotective effect of ischemic preconditioning in ovariectomized rat heart

Kumar, Vimal; Goyal, Ahsas; Gupta, Jeetendra Kumar.
Braz. J. Pharm. Sci. (Online); 58 (), 2022
Abstract Ischemic heart disease is the leading cause of death in postmenopausal women. The activity of heart ACE increases whereas the activity of ACE-2 decreases after menopause. The present study was designed to investigate the role of ACE and ACE-2 in the abrogated cardioprotective effect of IPC in OV...
Ovariectomía/clasificación, Captopril/farmacología, Corazón/fisiopatología, Infarto/patología, Infarto del Miocardio/patología, Inhibidores de la Enzima Convertidora de Angiotensina/efectos adversos, Isquemia Miocárdica, Mujeres
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Do avanafil and zaprinast exert positive effects on bone tissue via the nitric oxide/cyclic guanosine monophosphate/protein kinase-G signaling pathway in rats with ovariectomy-induced osteoporosis?

Huyut, Zübeyir; Bakan, Nuri; Yıldırım, Serkan.
Braz. J. Pharm. Sci. (Online); 57 (), 2021
Phosphodiesterase-5 inhibitors (PDE-5Is) exert positive effects on bone healing and mineralization by activation the nitric oxide/cyclic guanosine monophosphate/protein kinase-G (NO/cGMP/PKG) signaling pathway. In this study, the effects of zaprinast and avanafil, two PDE-5Is, on the NO signaling pathway...
Densidad Ósea/fisiología, Osteoporosis/complicaciones, Ovariectomía/clasificación, Estrés Oxidativo, Atrofia/prevención & control, Dosis Única/clasificación, Fosfodiesterasas de Nucleótidos Cíclicos Tipo 5, Huesos, Proteínas Quinasas
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