LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Effects of trichostatin A on FHIT and WWOX genes expression, cell growth inhibition and apoptosis induction in hepatocellular carcinoma WCH 17 cell line

Sanaei, Masumeh; Kavoosi, Fraidoon; Karami, Hossein.

Braz. J. Pharm. Sci. (Online); 57 (), 2021

Previously, we evaluated the effect of trichostatin A (TSA) on the expression of DNA methyltransferase 1 (DNMT1) in Hepatocellular Carcinoma (HCC). Fragile histidine triad (FHIT) and WW domain-containing oxidoreductase (WWOX) are two of the most common down-regulated genes in many cancers located on chro...

Oxidorreductasa que Contiene Dominios WW, Apoptosis/fisiología, Carcinoma Hepatocelular/patología, Citometría de Flujo/instrumentación, Crecimiento/fisiología, Cromosomas/clasificación, Neoplasias/clasificación

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Immunohistochemical WWOX expression and association with angiogenesis, p53 expression, cell proliferation and clinicopathological parameters in cervical cancer

Seabra, Mariana Ataydes Leite; Cândido, Eduardo Batista; Vidigal, Paula Vieira Teixeira; Lamaita, Rivia Mara; Rodrigues, Angélica Nogueira; Silva Filho, Agnaldo Lopes da.

Rev. bras. ginecol. obstet; 40 (2), 2018

Abstract Objective The current study evaluated the expression of WW domain-containing oxidoreductase (WWOX), its association with clinicopathological features and with p53, Ki-67 (cell proliferation) and CD31 (angiogenesis) expression in patients with invasive cervical squamous cell carcinoma (ICSCC). ...

Carcinoma de Células Escamosas/química, Carcinoma de Células Escamosas/genética, Carcinoma de Células Escamosas/patología, Proliferación Celular, Regulación Neoplásica de la Expresión Génica, Inmunohistoquímica, Persona de Mediana Edad, Neovascularización Patológica, Estudios Prospectivos, Proteína p53 Supresora de Tumor/análisis, Proteína p53 Supresora de Tumor/genética, Proteínas Supresoras de Tumor/análisis, Proteínas Supresoras de Tumor/genética, Neoplasias del Cuello Uterino/química, Neoplasias del Cuello Uterino/genética, Neoplasias del Cuello Uterino/patología, Oxidorreductasa que Contiene Dominios WW/análisis, Oxidorreductasa que Contiene Dominios WW/genética

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RUNX2 and WWOX genes as molecular biomarkers and candidates for targeted therapy in Egyptian patients with primary conventional osteosarcoma

Bahnassy, AA; Abdelzaher, E; Gaber, R; Elhosseiny, G; Rafalla, AAMA; Zekri, A-RN; El-Bastawisi, A; Yosif, HF; Younis, K.

Appl. cancer res; 36 (), 2016

Background: The conventional osteosarcoma (OS) is the commonest primary malignant, bone tumor with complex genomic profiles and poor survival. Runt-related transcription factor 2 (RUNX2) and WW domain containing oxidoreductase (WWOX) genes are implicated in normal osteogenesis as well as in the developme...

Osteosarcoma, Biomarcadores de Tumor/genética, ARN, Subunidad alfa 1 del Factor de Unión al Sitio Principal, Diferenciación Celular, Oxidorreductasa que Contiene Dominios WW, Estudios Retrospectivos, Terapia Molecular Dirigida

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