BACKGROUND: Spermatogonial stem cells (SSCs) are critical for sustaining spermatogenesis. Even though several regulators of SSC have been identified in rodents, the regulatory mechanism of SSC in humans has yet to be discovered. METHODS: To explore the regulatory mechanisms of human SSCs, we analyzed pub...
OBJECTIVES: To investigate the predictive value of long non-coding RNA (lncRNA) H19 and the ten-eleven translocation enzyme 1 (TET1) transcriptional expression in postoperative recurrence of uterine fibroids (UFs). METHODS: Seventy-five patients with UF, who underwent surgical treatment, were enrolled i...
Abstract: Objective: The feasibility of the use of WHO impregnated paper and biochemical assays to determine lethal concentrations (LC50 and LC99) and insecticide metabolic enzyme levels of Triatoma dimidiata. Materials and methods: LC50 and LC99 were calculated with WHO papers impregnated at different...
Resistencia a los Insecticidas,
Insecticidas/toxicidad,
Malatión/toxicidad,
Nitrilos/toxicidad,
Propoxur/toxicidad,
Piretrinas/toxicidad,
Triatoma/efectos de los fármacos,
Acetilcolinesterasa/análisis,
Sistema Enzimático del Citocromo P-450/análisis,
Esterasas/análisis,
Estudios de Factibilidad,
Glutatión Transferasa/análisis,
Dosificación Letal Mediana,
Oxigenasas de Función Mixta/análisis,
Ninfa/efectos de los fármacos,
Ninfa/enzimología,
Triatoma/enzimología,
Organización Mundial de la Salud
Brunoni, Andre R.;
Carracedo, Angel;
Amigo, Olalla M.;
Pellicer, Ana L.;
Talib, Leda;
Carvalho, Andre F.;
Lotufo, Paulo A.;
Benseñor, Isabela M.;
Gattaz, Wagner;
Cappi, Carolina.
Objective: We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532),...
Antidepresivos/uso terapéutico,
Antidepresivos de Segunda Generación/uso terapéutico,
Factor Neurotrófico Derivado del Encéfalo/genética,
Catecol O-Metiltransferasa/genética,
Citalopram/uso terapéutico,
Terapia Combinada,
Trastorno Depresivo Mayor/genética,
Trastorno Depresivo Mayor/terapia,
Método Doble Ciego,
Persona de Mediana Edad,
Polimorfismo de Nucleótido Simple,
Receptor de Serotonina 5-HT2A/genética,
Proteínas de Transporte de Serotonina en la Membrana Plasmática/genética,
Estimulación Transcraneal de Corriente Directa,
Resultado del Tratamiento,
Oxigenasas de Función Mixta/genética
Abstract Copper mine drainages are restricted environments that have been overlooked as sources of new biocatalysts for bioremediation and organic syntheses. Therefore, this study aimed to determine the enzymatic activities (esterase, epoxide hydrolase and monooxygenase) of 56 heterotrophic bacteria isol...
Bacterias/clasificación,
Bacterias/enzimología,
Cobre,
Microbiología Ambiental,
Minería,
Bacterias/genética,
Bacterias/aislamiento & purificación,
Enzimas,
Esterasas/genética,
Esterasas/metabolismo,
Oxigenasas de Función Mixta/genética,
Oxigenasas de Función Mixta/metabolismo,
Oxidación-Reducción,
Filogenia,
ARN Ribosómico 16S/genética,
Análisis de Secuencia de ADN,
Sulfuros/metabolismo
Congenital adrenal hyperplasia due to deficiency of the enzyme 21-hydroxylase (21-OH), is distinguished in its classical and nonclassical form and it is also one of the most common autosomal recessive inherited diseases in humans. The classical form appears in a rate between 1:5 000 and 1:15 000 among th...
Brugmansia candida (Solanaceae) is a native tree distributed across South-American and produces the pharmacologically- important group of tropane alkaloids including scopolamine. This biocompound is synthesised from hyoscyamine by action of Hyoscyamine 6-â hydroxylase (H6H, EC 1.14.11.11) at the end of ...
Brugmansia/genética,
Raíces de Plantas/genética,
Solanaceae/genética,
Análisis de Secuencia de ARN,
Transformación Genética,
Secuencia de Bases,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Bases de Datos de Ácidos Nucleicos,
Clonación Molecular,
Oxigenasas de Función Mixta/genética,
Brugmansia/enzimología,
Solanaceae/enzimología,
Raíces de Plantas/enzimología,
ADN Complementario,
Biología Computacional,
Escopolamina/metabolismo,
Oxigenasas de Función Mixta/metabolismo
As dosagens de testosterona, sulfato de deidroepiandrosterona (SDHEA) e cortisol no líquido amniótico (LA) permitem avaliar as funçöes das adrenais e das gônadas fetais. Estudamos LAs de 41 gestaçöes, obtidos por amniocentese no segundo trimestre da gestaçäo. Trinta e sete destas gestaçöes (da...
A resposta de 17-alfa-OHD e cortisol ao estimulo com ACTH em individuos heterozigotos (HTZ) e homozigostos para hiperplasia adrenal congenita por deficiencia da 21-hidroxilase foi comparada com individuos controles. Os niveis basais ou estimulos de conrtisol nao apresentaram nenhuma diferenca entre os HT...
