Ubiquitin protein E3 ligase ASB9 suppresses proliferation and promotes apoptosis in human spermatogonial stem cell line by inducing HIF1AN degradation
Biol. Res; 56 (), 2023
BACKGROUND: Spermatogonial stem cells (SSCs) are critical for sustaining spermatogenesis. Even though several regulators of SSC have been identified in rodents, the regulatory mechanism of SSC in humans has yet to be discovered. METHODS: To explore the regulatory mechanisms of human SSCs, we analyzed pub...
Testículo/metabolismo, Ubiquitina-Proteína Ligasas/metabolismo, Ubiquitinas/metabolismo, Proteínas Supresoras de la Señalización de Citocinas/metabolismo, Espermatogénesis/fisiología, Proteínas Represoras/metabolismo, Oxigenasas de Función Mixta/metabolismo, Proliferación Celular, Línea Celular, Apoptosis