LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Changes in digestive enzymes activities during the initial ontogeny of wolf cichlid, Parachromis dovii (Perciformes: Cichlidae)

Wolf cichlid, Parachromis dovii, is a species with a high potential for aquaculture in Central America; however, the knowledge of the digestive physiology in larvae period is limited. For these reason, this study evaluated the changes on digestive enzymes (alkaline and acid proteases, trypsin, chymotryps...

Target-directed catalytic metallodrugs

Joyner, J C; Cowan, J A.

Braz. j. med. biol. res; 46 (6), 2013

Most drugs function by binding reversibly to specific biological targets, and therapeutic effects generally require saturation of these targets. One means of decreasing required drug concentrations is incorporation of reactive metal centers that elicit irreversible modification of targets. A common appro...

Disponibilidad Biológica, Catálisis, Complejos de Coordinación/farmacocinética, Genes env, Terapia Molecular Dirigida/métodos, Oxidación-Reducción, Péptido Hidrolasas/síntesis química, Péptido Hidrolasas/farmacocinética, Peptidil-Dipeptidasa A/metabolismo, Especies Reactivas de Oxígeno/farmacología

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