BACKGROUND: Osteoporosis attacks approximately 10% of the population worldwide. Sika Deer (Cervus nippon), one of China’s precious traditional medicinal animals, has been widely recorded in ancient Chinese medical books and claimed for centuries to have numerous medical benefits including bone strength...
BACKGROUND: Cecropin P1, acting as an antimicrobial, has a broad-spectrum antibacterial activity with some antiviral and antifungal properties. It is a promising natural alternative to antibiotics which is originally isolated from the pig intestinal parasitic nematode Ascaris suum. Many studies have show...
Proteins and peptides are the most diverse biomolecules found in nature and make our interest due to their wide applications in food and pharmaceutical industry. Angiotensin Converting Enzyme (ACE) plays a major role in controlling blood pressure. The inhibition of ACE with peptides is a main target in t...
Espectrometría de Masas,
Cromatografía Liquida/métodos,
Péptidos/farmacología,
Proteínas/farmacología,
Suplementos Dietéticos,
Hipertensión/terapia,
Concentración de Iones de Hidrógeno,
Antihipertensivos/análisis,
Optimización de Procesos/clasificación,
Hidrolisados de Proteína/farmacología,
Proteínas de Soja/farmacología
Graziani, D;
Ribeiro, J V V;
Cruz, V S;
Gomes, R M;
Araújo, E G;
Santos Júnior, A C M;
Tomaz, H C M;
Castro, C H;
Fontes, W;
Batista, K A;
Fernandes, K F;
Xavier, C H.
About 3000 tons of beans are not used in human food due to hardening. Several studies on bean-derived bioactive peptides have shown potential to treat some diseases, including those relying on oxidative dysfunctions. We assessed the effects of peptides extracted from hardened bean Phaseolus vulgaris (PV)...
Non-alcoholic fatty liver disease (NAFLD) is a common disease associated with metabolic syndrome and can lead to life-threatening complications like hepatic carcinoma and cirrhosis. Exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist antidiabetic drug, has the capacity to overcome insulin resis...
Dioxigenasa FTO Dependiente de Alfa-Cetoglutarato/efectos de los fármacos,
Dioxigenasa FTO Dependiente de Alfa-Cetoglutarato/genética,
Glucemia/análisis,
Peso Corporal/efectos de los fármacos,
Cromonas/metabolismo,
Dieta Alta en Grasa,
Modelos Animales de Enfermedad,
Ingestión de Alimentos/efectos de los fármacos,
Inhibidores Enzimáticos/metabolismo,
Exenatida,
Hígado Graso/metabolismo,
Hígado Graso/patología,
Regulación de la Expresión Génica/efectos de los fármacos,
Técnicas In Vitro,
Insulina/sangre,
Malondialdehído/análisis,
Morfolinas/metabolismo,
Enfermedad del Hígado Graso no Alcohólico/tratamiento farmacológico,
Obesidad/metabolismo,
Péptidos/farmacología,
Sustancias Protectoras/farmacología,
Ponzoñas/farmacología
Abstract Purpose: To investigate the inflammatory and redox responses to teduglutide on an animal model of laparotomy and intestinal anastomosis. Methods: Wistar rats (n=62) were allocated into four groups: "Ileal Resection and Anastomosis" vs. "Laparotomy", each one split into "Postoperative Teduglut...
Antiinflamatorios/farmacología,
Íleon/efectos de los fármacos,
Íleon/patología,
Íleon/cirugía,
Oxidación-Reducción/efectos de los fármacos,
Péptidos/farmacología,
Anastomosis Quirúrgica,
Apoptosis,
Supervivencia Celular/efectos de los fármacos,
Citocinas/sangre,
Modelos Animales de Enfermedad,
Citometría de Flujo,
Íleon/metabolismo,
Laparotomía,
Estrés Oxidativo/efectos de los fármacos,
Distribución Aleatoria,
Ratas Wistar,
Reproducibilidad de los Resultados,
Factores de Tiempo,
Resultado del Tratamiento,
Cicatrización de Heridas/efectos de los fármacos
Introdução: Doenças cardiovasculares constituem importante causa de morte em todo mundo e a hipercolesterolemia está diretamente relacionada a este problema de saúde pública. A dieta desempenha papel importante neste processo e alguns alimentos, como o amaranto (Amaranthus cruentus L. BRSAlegria), ...
Abstract Alzheimer disease (AD) is the most prevalent form of dementia of adult-onset, characterized by progressive impairment in cognition and memory. There is no cure for the disease and the current treatments are only symptomatic. Drug discovery is an expensive and time-consuming process; in the last ...
ABSTRACT Introduction: We investigate the effect of active peptide from Urechis unicinctus (UU) by high temperature/pressure and ultra-wave assisted lysis on erectile dysfunction in streptozotocin-induced diabetic rats. Materials and Methods: Forty 12-week-old Sprague-Dawley rats were used in this stud...
Anélidos/química,
Células Cultivadas,
Diabetes Mellitus Experimental/inducido químicamente,
Diabetes Mellitus Experimental/complicaciones,
Disfunción Eréctil/tratamiento farmacológico,
Disfunción Eréctil/etiología,
Disfunción Eréctil/fisiopatología,
Pene/efectos de los fármacos,
Péptidos/análisis,
Péptidos/farmacología,
Péptidos/uso terapéutico,
Distribución Aleatoria,
Ratas Sprague-Dawley,
Estreptozocina,
Temperatura
In this study, a novel approach for compression of matrix pellets into disintegrating tablets has been studied in an attempt to overcome the issues pertaining to rupture of polymer coat during compression of reservoir-type pellets. Extended release matrix pellets were prepared by the extrusion/spheroniza...
