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Neuroprotective effects of the PPARβ/δ antagonist GSK0660 in in vitro and in vivo Parkinson's disease models

Antonosante, Andrea; Castelli, Vanessa; Sette, Martina; Alfonsetti, Margherita; Catanesi, Mariano; Benedetti, Elisabetta; Ardini, Matteo; Cimini, Annamaria; dAngelo, Michele.
Biol. Res; 56 (), 2023
BACKGROUND: The underlying mechanism of Parkinson's disease are still unidentified, but excitotoxicity, oxidative stress, and neuroinflammation are considered key actors. Proliferator activated receptors (PPARs) are transcription factors involved in the control of numerous pathways. Specifically, PPARβ/...
Fármacos Neuroprotectores/farmacología, PPAR-beta, Enfermedad de Parkinson/tratamiento farmacológico, Oxidopamina, Complejo de la Endopetidasa Proteasomal
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Phytohormone abscisic acid boosts pentobarbital-induced sleep through activation of GABA-A, PPARβ and PPARγ receptor signaling

Madadzadeh, Mohammad; Abbasnejad, Mehdi; Mollashahi, Mahtab; Pourrahimi, Ali Mohammad; Esmaeili-Mahani, Saeed.
Arq. neuropsiquiatr; 79 (3), 2021
ABSTRACT Background: Sleep disorders induce anxiety and forgetfulness and change habits. The chemical hypnotic drugs currently used have serious side effects and, therefore, people are drawn towards using natural compounds such as plant-based healing agents. Abscisic acid (ABA) is produced in a variety...
Ácido Abscísico/farmacología, PPAR gamma/metabolismo, PPAR-beta/metabolismo, Pentobarbital/farmacología, Reguladores del Crecimiento de las Plantas/farmacología, Ratas Wistar, Receptores de GABA-A/metabolismo, Transducción de Señal, Sueño
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Nrf2, NF-κB and PPARβ/δ mRNA Expression Profile in Patients with Coronary Artery Disease

Barbosa, Jaqueline Ermida; Stockler-Pinto, Milena Barcza; Cruz, Beatriz Oliveira da; Silva, Ana Carla Tavares da; Anjos, Juliana Saraiva; Mesquita, Claudio Tinoco; Mafra, Denise; Cardozo, Ludmila F M F.
Arq. bras. cardiol; 113 (6), 2019
Abstract Background: Oxidative stress and inflammation are present in coronary artery disease (CAD) and are linked to the activation of the transcription nuclear factor kappa B (NF-κB). To attenuate these complications, transcription factors like nuclear factor erythroid 2-related factor 2 (Nrf2) a...
Biomarcadores/metabolismo, Índice de Masa Corporal, Enfermedad de la Arteria Coronaria/metabolismo, Regulación de la Expresión Génica, Inflamación/metabolismo, Factor 2 Relacionado con NF-E2/metabolismo, FN-kappa B/metabolismo, Estrés Oxidativo, PPAR delta/metabolismo, PPAR-beta/metabolismo, Reacción en Cadena de la Polimerasa, ARN Mensajero/metabolismo
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