BACKGROUND: In 2020, the first vaccines were approved, according to the WHO. However, speculations arose regarding their efficacy and post-vaccination adverse events (AEFV). OBJECTIVE: To evaluate the prevalence of headache as AEFI from the SARSCoV-2 vaccine in Piauí, B...
A Dengue induz uma resposta exacerbada e transitória das células secretoras de anticorpos (ASCs) no sangue de pacientes cerca de sete dias após o início dos sintomas. A frequência dessas ASCs chega a representar mais de 50% de todas as células B circulantes neste período. No entanto, ainda é desc...
Abstract he innate immune response plays an important role in the pathophysiology of acute respiratory distress syndrome (ARDS); however, no drug has been proven to be beneficial in the management of ARDS. Therefore, the aim of this study was to investigate the effects of using combined sedatives on syst...
Abstract The University Pharmacy Program (FU), from the Federal University of Rio de Janeiro (UFRJ), was created based on the need to offer a curricular internship to students of the Undergraduate Course at the Faculty of Pharmacy. Currently, it is responsible for the care of about 200 patients/day, offe...
Diretrizes clínicas (DCs) de alta qualidade são importantes para a assistência efetiva de pacientes com doenças crônicas, incluindo a depressão. A depressão é um dos principais problemas de saúde mundial, sendo um dos transtornos psiquiátricos mais comumente encontrados na prática médica, afe...
Guía de Práctica Clínica,
Depresión/tratamiento farmacológico,
Trastorno Depresivo Resistente al Tratamiento/diagnóstico,
Trastorno Depresivo/diagnóstico,
Medicina Basada en la Evidencia/clasificación,
Pacientes/clasificación,
Antidepresivos/administración & dosificación,
d0000748220,
d0039330,
ddcs0518110,
Grupo de Atención al Paciente/ética,
d0043580
Com base nas perturbações fosfoproteômicas de moléculas associadas ao ciclo celular em células infectadas pelo coronavírus causador da síndrome respiratória aguda grave (SARSCoV)-2, a hipótese de inibidores do ciclo celular como uma terapia potencial para a doença de coronavírus 2019 (COVID-19...
Ciclo Celular/inmunología,
Pacientes/clasificación,
COVID-19/patología,
Proteoma/análisis,
Espectrometría de Masas/métodos,
Transcriptoma/inmunología,
Análisis de Secuencia de ARN/instrumentación,
Coronavirus/patogenicidad,
Cromosomas/metabolismo,
Células Asesinas Naturales/clasificación,
Enfermedades Respiratorias/patología,
d0188440,
d0123130,
ddcs0500220,
d0454730,
d0127200
Cardiovascular diseases involve hyperlipidemia, inflammation and oxidative stress. Although this relationship is well established, only biomarkers associated with hyperlipidemia and inflammation are currently in clinical practice for diagnosis and evaluation of patient treatment. Our hypothesis is that o...
Abstract Teicoplanin is a glycopeptide antibiotic commonly used to treat Gram-positive bacterial infections in the clinic. The aim of this study was to provide a therapeutic reference for the clinical application and dosage regimen adjustment of teicoplanin by identifying factors associated with its plas...
Abstract Inborn errors of metabolism are rare disorders with few therapeutic options for their treatments, which can make patients suffer with complications. Therefore, compounded drugs might be a promising option given that they have the ability of meeting the patient's specific needs, (i) identificatio...
Loures, Cristina de Mello Gomide;
Guimarães, Tânia Mara Pinto Dabés;
Ferreira, Karine Silveste;
Silva, Marcos Vinicius Ferreira;
Alves, Luan Carlos Vieira;
Cicarini, Walter Batista;
Nunes, Fernanda Freire Campos;
Consoli, Renato Vargas;
Neiva, Cláudia Lopes Santoro;
Pádua, Paulo Madureira de;
Santos, Luara Isabela dos;
Moreira, Josimar Dornelas;
Toledo, Vicente de Paulo Coelho Peixoto de;
Carvalho, Maria das Graças.
Abstract The pathogenesis of systemic lupus erythematosus (SLE) is complex. Few studies in Brazilian population have addressed cell phenotypes associated with immunological responses and their associations with SLE activity. The aim of this study is to investigate cell phenotypes associated to SLE diagno...
