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Low-dose paclitaxel modulates the cross talk between the JNK and Smad signaling in primary biliary fibroblasts

Lu, Jiamei; Yu, Liang; Shi, Jianhua.
Rev. Assoc. Med. Bras. (1992, Impr.); 68 (2), 2022
SUMMARY OBJECTIVE: The objective of this study was to explore the molecular mechanism underlying the occurrence of benign bile duct stricture and the target of low-dose paclitaxel in the prevention of benign bile duct stricture. METHODS: Under the stimulation of transforming growth factor beta 1, the e...
Colágeno, Colágeno Tipo I/metabolismo, Colágeno Tipo I/farmacología, Fibroblastos/metabolismo, Sistema de Señalización de MAP Quinasas, Paclitaxel/farmacología, Proteína Smad2
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Investigation of effect of paclitaxel on netrin 1 and factor 8 in Ehrlich solid tumors

Kaymak, Emin; Ertekin, Tolga; Özdamar, Saim.
Int. j. morphol; 39 (2), 2021
SUMMARY: Cancer known as a malignant tumor, is a class of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. The Ehrlich tumor is a mammary adenocarcinoma of mice developed in solid and ascitic forms. This study was aimed to investigate the effects ...
Carcinoma de Ehrlich/tratamiento farmacológico, Paclitaxel/administración & dosificación, Antineoplásicos Fitogénicos/administración & dosificación, Paclitaxel/farmacología, Antineoplásicos Fitogénicos/farmacología, Netrina-1/antagonistas & inhibidores, Factor VIII, Apoptosis, Inmunohistoquímica, Ratones Endogámicos BALB C, Neovascularización Patológica, Densidad Microvascular/efectos de los fármacos, Proliferación Celular/efectos de los fármacos
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Uso combinado de sinvastatina e paclitaxel associado à nanoemulsão lipídica no tratamento do câncer

Kretzer, Iara Fabricia.
Uma nova alternativa para o tratamento do câncer foi proposta em estudos anteriores, consistindo no uso de uma nanoemulsão lipídica como transportadora de agentes quimioterápicos às células neoplásicas. A redução da toxicidade da quimioterapia promovida pelo direcionamento específico de quimiot...
Paclitaxel/farmacología, Simvastatina/farmacología, Terapia Molecular Dirigida, Agencias Voluntarias de Salud/22074, Neoplasias, Quimioterapia/métodos, Preparaciones Farmacéuticas/análisis
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