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Suppression of L-arginine-induced acute necrotizing pancreatitis in rats by metformin associated with the inhibition of myeloperoxidase and activation of interleukin-10

Al-Hashem, Fahaid.
Int. j. morphol; 39 (1), 2021
SUMMARY: Acute pancreatitis is a frequent life-threatening inflammatory disease of the pancreas characterized by severe abdominal pain that lasts for days to weeks. We sought to determine whether the antidiabetic and anti-inflammatory drug, metformin can substantially protect against acute pancreatitis i...
Pancreatitis Aguda Necrotizante/tratamiento farmacológico, Pancreatitis Aguda Necrotizante/inducido químicamente, Arginina/toxicidad, Metformina/administración & dosificación, Peroxidasa/antagonistas & inhibidores, Interleucina-10/metabolismo, Modelos Animales de Enfermedad, Interleucina-10, Ratas Wistar, Páncreas/efectos de los fármacos, Sustancias Protectoras, L-Lactato Deshidrogenasa/antagonistas & inhibidores, Factor de Necrosis Tumoral alfa/antagonistas & inhibidores
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Ameliorative effect of certolizumab on experimentally induced acute necrotic pancreatitis in rats

Kosekli, Mehmet Ali; Herek, Özkan; Ozmen, Özlem; Sahinduran, Sima.
Rev. Assoc. Med. Bras. (1992, Impr.); 65 (2), 2019
SUMMARY OBJECTIVE: The effects of Certolizumab, a pegylated monoclonal antibody to tumor necrosis factor α, on experimentally induced acute pancreatitis (AP) were examined. METHODS: Thirty-six Wistar Albino male rats were randomly divided into four groups. Group I was the control group and no medi...
Certolizumab Pegol/uso terapéutico, Modelos Animales de Enfermedad, Inmunosupresores/uso terapéutico, Pancreatitis Aguda Necrotizante/inducido químicamente, Pancreatitis Aguda Necrotizante/tratamiento farmacológico, Pancreatitis Aguda Necrotizante/patología, Ratas Wistar, Ácido Taurocólico
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Effects of diazoxide in experimental acute necrotizing pancreatitis

de Oliveira Andrade, Roberta; Kunitake, Tiago; Koike, Marcia Kiyomi; Machado, Marcel C C; Souza, Heraldo Possolo.
Clinics; 72 (2), 2017
OBJECTIVE: We aimed to assess the effects of diazoxide on the mortality, pancreatic injury, and inflammatory response in an experimental model of acute pancreatitis. METHODS: Male Wistar rats (200-400 g) were divided randomly into two groups. Fifteen minutes before surgery, animals received physiologica...
Colagogos y Coleréticos, Diazóxido/administración & dosificación, Diazóxido/farmacología, Modelos Animales de Enfermedad, Pancreatitis Aguda Necrotizante/inducido químicamente, Pancreatitis Aguda Necrotizante/tratamiento farmacológico, Pancreatitis Aguda Necrotizante/mortalidad, Pancreatitis Aguda Necrotizante/patología, Distribución Aleatoria, Ratas Wistar, Ácido Taurocólico, Vasodilatadores/administración & dosificación, Vasodilatadores/farmacología
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