LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Increased peripheral blood TCD4+ counts and serum SP-D levels in patients with chronic paracoccidioidomycosis, during and after antifungal therapy

Venturini, James; Cavalcante, Ricardo Souza; Sylvestre, Tatiane Fernanda; Santos, Rodolfo Ferreira dos; Moris, Daniela Vanessa; Carvalho, Lídia Raquel; Arruda, Maria Sueli Parreira de; Golim, Marjorie de Assis; Mendes, Rinaldo Poncio.

Mem. Inst. Oswaldo Cruz; 112 (11), 2017

BACKGROUND The main clinical forms of paracoccidioidomycosis (PCM) are the acute/subacute form (AF) and the chronic form (CF), and they both display considerable clinical variability. The immune responses of PCM patients, during and after treatment, remain neglected, mainly in the case of CF patients, du...

Antifúngicos/uso terapéutico, Biomarcadores/sangre, Recuento de Linfocito CD4, Citocinas/sangre, Citometría de Flujo, Paracoccidioidomicosis/sangre, Paracoccidioidomicosis/tratamiento farmacológico, Proteína D Asociada a Surfactante Pulmonar/sangre, Índice de Severidad de la Enfermedad

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Recombinant 60-kDa heat shock protein from Paracoccidioides brasiliensis: is it a good antigen for serological diagnosis of paracoccidioidomycosis?

Paracoccidioides brasiliensis and P. lutzii are fungi that cause paracoccidioidomycosis (PCM), the most prevalent systemic mycosis in South America. For serological diagnosis, although 43-kDa glycoprotein (gp43) is regarded as highly specific for PCM, the occurrence of false negative reactions in sera fr...