Sunitinib in the therapy of malignant paragangliomas: report on the efficacy in a SDHB mutation carrier and review of the literature
Arch. endocrinol. metab. (Online); 61 (1), 2017
SUMMARY Metastatic pheochromocytomas (PHEOs) and paragangliomas (sPGLs) are rare neural crest-derived tumors with a poor prognosis. About 50% of them are due to germ-line mutations of the SDHB gene. At present, there is no cure for these tumors. Their therapy is palliative and represented by different op...
Inhibidores de la Angiogénesis/uso terapéutico, Antineoplásicos/uso terapéutico, Indoles/uso terapéutico, Mutación/genética, Metástasis de la Neoplasia, Paraganglioma/irrigación sanguínea, Paraganglioma/tratamiento farmacológico, Paraganglioma/genética, Pirroles/uso terapéutico, Succinato Deshidrogenasa/genética, Sunitinib, Resultado del Tratamiento