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Antiparasitic and anti-inflammatory activities of ß-lapachone-derived naphthoimidazoles in experimental acute Trypanosoma cruzi infection

Cascabulho, Cynthia M; Meuser-Batista, Marcelo; Moura, Kelly Cristina G de; Pinto, Maria do Carmo; Duque, Thabata Lopes Alberto; Demarque, Kelly C; Guimarães, Ana Carolina Ramos; Manso, Pedro Paulo de Abreu; Pelajo-Machado, Marcelo; Oliveira, Gabriel M; Castro, Solange L De; Menna-Barreto, Rubem FS.
Mem. Inst. Oswaldo Cruz; 115 (), 2020
BACKGROUND Chagas disease, which is caused by the protozoan Trypanosoma cruzi, is endemic to Latin America and mainly affects low-income populations. Chemotherapy is based on two nitrocompounds, but their reduced efficacy encourages the continuous search for alternative drugs. Our group has characterise...
Enfermedad Aguda, Antiinflamatorios, Enfermedad de Chagas/tratamiento farmacológico, Modelos Animales de Enfermedad, Electrocardiografía, Naftoquinonas/química, Naftoquinonas/uso terapéutico, Nitroimidazoles/química, Nitroimidazoles/uso terapéutico, Parasitemia/tratamiento farmacológico, Factores de Tiempo, Tripanocidas/química, Tripanocidas/uso terapéutico
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Efficacy of the Benznidazole+Posaconazole combination therapy in parasitemia reduction: An experimental murine model of acute Chagas

Echeverría, Luis Eduardo; González, Clara Isabel; Hernandez, Julio Cesar Mantilla; Díaz, Martha Lucia; Eduardo Nieto, Javier; López-Romero, Luis Alberto; Rivera, Julián David; Suárez, Edwin Uriel; Ochoa, Sergio Alejandro Gómez; Rojas, Lyda Z; Morillo, Carlos A.
Rev. Soc. Bras. Med. Trop; 53 (), 2020
Abstract INTRODUCTION: Benznidazole (BZL) and Nifurtimox (NFX) are the pharmacological treatment for acute phase Chagas Disease (CD); however, therapy resistance and residual mortality development remain important unresolved issues. Posaconazole (POS) has shown a trypanocidal effect in vivo and in vitr...
Enfermedad Aguda, Enfermedad de Chagas/tratamiento farmacológico, ADN Protozoario, Modelos Animales de Enfermedad, Progresión de la Enfermedad, Quimioterapia Combinada, Nitroimidazoles/administración & dosificación, Carga de Parásitos, Parasitemia/tratamiento farmacológico, Ratas Wistar, Triazoles/administración & dosificación, Tripanocidas/administración & dosificación
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Evaluation of antioxidant therapy in experimental Chagas disease

Tieghi, Thais de Mello; Manca, Camilla Chimelo; Garcia, Lígia Cangussu Tomaz; Castanho, Roberto Esteves Pires; Therezo, Altino Luiz Silva; Frei, Fernando; Taipeiro, Elane de Fátima; Martins, Luciamáre Perinetti Alves.
Rev. Soc. Bras. Med. Trop; 50 (2), 2017
Abstract INTRODUCTION: Stimulation of inflammatory mediators such as cytokines and chemokines may cause oxidative stress in Chagas disease. In this study, we evaluated the merit of vitamins C and E as antioxidant therapy to minimize the oxidative stress-induced damage in an experimental model of Chagas...
Enfermedad Aguda, Antioxidantes/uso terapéutico, Ácido Ascórbico/uso terapéutico, Enfermedad de Chagas/terapia, Enfermedad de Chagas/metabolismo, Enfermedad Crónica, Modelos Animales de Enfermedad, Ratones, Estrés Oxidativo/efectos de los fármacos, Parasitemia/tratamiento farmacológico, Vitamina E/uso terapéutico
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