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Endogenous and exogenous serotonin, but not sumatriptan, ameliorate seizures and neuroinflammation in the pentylenetetrazole-induced seizure model in rats

Torun, Ibrahim Ethem; Kılınc, Yasemin Baranoglu; Kilinc, Erkan.
Arq. neuropsiquiatr; 80 (1), 2022
ABSTRACT Background: Epilepsy has neuropsychiatric comorbidities such as depression, bipolar disorder, and anxiety. Drugs that target epilepsy may also be useful for its neuropsychiatric comorbidities. Objective: To investigate the effects of serotonergic modulation on pro-inflammatory cytokines and th...
Anticonvulsivantes/efectos adversos, Epilepsia/tratamiento farmacológico, Fluoxetina/efectos adversos, Interleucina-6, Pentilenotetrazol/efectos adversos, Ratas Wistar, Convulsiones/inducido químicamente, Convulsiones/tratamiento farmacológico, Serotonina/efectos adversos, Sumatriptán/efectos adversos, Factor de Necrosis Tumoral alfa
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Modulatory effects of neuropeptides on pentylenetetrazol-induced epileptic seizures and neuroinflammation in rats

Kilinc, Erkan; Gunes, Handan.
Rev. Assoc. Med. Bras. (1992, Impr.); 65 (9), 2019
SUMMARY OBJECTIVE We aimed to explore the effects of neuropeptides ghrelin, obestatin, and vasoactive intestinal peptide (VIP) on seizures and plasma concentrations of neuroinflammation biomarkers including calcitonin gene-related peptide (CGRP), substance-P (SP), and interleukin-1 beta (IL-1β) in...
Biomarcadores/sangre, Péptido Relacionado con Gen de Calcitonina/sangre, Péptido Relacionado con Gen de Calcitonina/efectos adversos, Convulsivantes/efectos adversos, Modelos Animales de Enfermedad, Ghrelina/farmacología, Inflamación, Interleucina-1beta/sangre, Interleucina-1beta/efectos adversos, Mioclonía, Neuropéptidos/efectos adversos, Pentilenotetrazol/efectos adversos, Hormonas Peptídicas/farmacología, Distribución Aleatoria, Ratas Wistar, Convulsiones/inducido químicamente, Convulsiones/metabolismo, Sustancia P/sangre, Sustancia P/efectos adversos, Factores de Tiempo, Péptido Intestinal Vasoactivo/farmacología
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1-triacontanol cerotate isolated from Marsilea quadrifolia Linn. safeguards hippocampal CA3 neurons and augments special memory deficit in chronic epileptic rats

Snehunsu, Adhikari; Nayak, Satheesha B; Kandwal, Mamta; Piyali, Adhikari; Adiga, Murali; Sahoo, Pabitra; Medabala, T; Raghavenra-Rao, K; Joseph, Alex.
Int. j. morphol; 37 (1), 2019
SUMMARY: Currently many people with epilepsy do not have seizure control even with the best available medications. Moreover various antiepileptics have adverse cognitive impact with other side effect. Thus, need for new antiepileptic drugs still remains challenge. However, many of the natural components ...
Epilepsia/tratamiento farmacológico, Marsileaceae/química, Enfermedad Crónica, Alcoholes Grasos/administración & dosificación, Ácidos Grasos, Hipocampo/efectos de los fármacos, Memoria Espacial/efectos de los fármacos, Región CA3 Hipocampal/efectos de los fármacos, Ratas Wistar, Pentilenotetrazol/efectos adversos, Alcoholes Grasos/aislamiento & purificación, Epilepsia/inducido químicamente, Células Piramidales, Prueba del Laberinto Acuático de Morris
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