Pin1 aggravates renal injury induced by ischemia and reperfusion in rats via Nrf2/HO-1 mediated endoplasmic reticulum stress
Acta cir. bras; 37 (1), 2022
Purpose:
To investigate the role of peptidyl-prolyl cis/trans isomerase 1 (Pin1) on renal ischemia-reperfusion (I/R) injury and underlying mechanism.
Methods:
By establishing the in vitro and in vivo models of renal I/R, the role of Pin1 was explored by using molecular assays.
Results:
In renal I/R, en...