Results: 69

Expression analysis of transcription factors in sugarcane during cold stress

Braz. j. biol; 83 (), 2023
Abstract Transcription factors (TF) are a wide class of genes in plants, and these can regulate the expression of other genes in response to various environmental stresses (biotic and abiotic). In the current study, transcription factor activity in sugarcane was examined during cold stress. Initially, RN...

The effects of repeated doses of xylazine-ketamine and medetomidineketamine anesthesia on DNA damage in the liver and kidney

Acta cir. bras; 38 (), 2023
Purpose: This study evaluated the DNA damage caused by repeated doses of xylazine-ketamine and medetomidine-ketamine anesthesia in the liver and kidneys. Methods: In this study, 60 rats were used. The rats were divided into group 1 (xylazine-ketamine), and group 2 (medetomidine-ketamine), and these anes...

O impacto da exposição química sobre o transcriptoma de trabalhadores formais e informais

Introdução: Exposições químicas podem variar em populações geograficamente distintas, com diferentes hábitos, estilos de vida e características individuais. Alguns elementos químicos encontrados no ambiente são capazes de alterar a expressão gênica humana. Objetivos: a) quantificar as concen...

The pattern of alternative splicing and DNA methylation alteration and their interaction in linseed (Linum usitatissimum L) response to repeated drought stresses

Biol. Res; 56 (), 2023
BACKGROUND: Drought stress has significantly hampered agricultural productivity worldwide and can also result in modifications to DNA methylation levels. However, the dynamics of DNA methylation and its association with the changes in gene transcription and alternative splicing (AS) under drought stress ...

Avaliação dos aspectos moleculares e sua relevância na resposta terapêutica e prognóstico de pacientes com câncer de bexiga submetidos a quimioterapia com cisplatina
Evaluation of molecular aspects and their relevance in therapeutic response and prognosis of patients with bladder cancer undergoing chemotherapy with cisplatin

INTRODUÇÃO: O câncer de bexiga é a 10a neoplasia maligna mais comum no mundo. O tipo músculo-invasivo tem como tratamento padrão-ouro combinações de quimioterapia e cirurgia. Muitos pacientes, no entanto, não respondem a quimioterapia e são submetidos a uma terapia ineficaz. Identificar quais p...

Análise do perfil de mRNAs diferencialmente traduzidos no carcinoma renal de células claras

O carcinoma renal de células claras (CRCC) é o tipo de neoplasia renal com maior incidência, cerca de 80%. A maioria dos casos são curados após cirurgia, porém, cerca de um terço dos pacientes apresentam recidiva da doença com metástase à distância. O tratamento para este tumor evoluiu muito n...

Transcriptomic modulation in response to an intoxication with deltamethrin in a population of Triatoma infestans with low resistance to pyrethroids

Plos negl. trop. dis; 16 (6), 2022
Background Triatoma infestans is the main vector of Chagas disease in the Southern Cone. The resistance to pyrethroid insecticides developed by populations of this species impairs the effectiveness of vector control campaigns in wide regions of Argentina. The study of the global transcriptomic response t...

Dinâmica das populações de Triatoma infestans no Chaco Paraguaio: Análise genética populacional da reinfestação domiciliar após controle vetorial
Dynamics of Triatoma infestans populations in the Paraguayan Chaco: Population genetic analysis of household reinfestation following vector control

Background Although domestic infestations by Triatoma infestans have been successfully controlled across Latin America, in areas of the Gran Chaco region, recurrent post-spraying house colonization continues to be a significant challenge, jeopardizing Chagas disease vector control and maintaining active ...

Brain Tumor Heterogeneity

Arq. bras. neurocir; 40 (3), 2021
Tumor heterogeneity is the concept that different tumor cells provide distinct biomorphological lesions, gene expressions, proliferation, microenvironment and graduated capacity of metastatic lesions. Brain tumor heterogeneity has been recently discussed about the interesting interaction of chronic infla...

Exploration of the core genes in ulcerative interstitial cystitis/bladder pain syndrome

Int. braz. j. urol; 47 (4), 2021
ABSTRACT Objective: Interstitial cystitis (IC)/bladder pain syndrome (BPS) is a chronic inflammatory disease that can cause bladder pain and accompanying symptoms, such as long-term urinary frequency and urgency. IC/BPS can be ulcerative or non-ulcerative. The aim of this study was to explore the core g...