Rosa, Gabriel de Lima;
Guzzo, Edson Muller;
Nunes, Silvia Elisandra Bitello;
Faverzani, Jéssica Lamberty;
Padilha, Rafael Bremm;
Lima, Amanda Muliterno Domingues Lourenço de;
Barbosa, Brayan Braz;
Vargas, Carmen Regla;
Siqueira, Ionara Rodrigues;
Coitinho, Adriana Simon.
A previous study revealed the protective effect of an aerobic exercise protocol on behavioral and inflammatory aspects in an animal model of epileptic seizures. The previously collected samples in that investigation were now analyzed from the perspective of oxidative stress. Five experimental groups of W...
SUMMARY: Etoposide is an effective antimitotic and antineoplastic agent used to treat various human malignancies. In the present study, Etoposide was injected intraperitoneally into the rats at 1 mg/kg/day for 52 days (52 doses). The control animals received physiological saline (0.5 ml) intraperitoneall...
Etopósido/administración & dosificación,
Etopósido/farmacología,
Peso Corporal/efectos de los fármacos,
Tamaño de los Órganos/efectos de los fármacos,
Peroxidación de Lípido,
Antioxidantes/administración & dosificación,
Antioxidantes/farmacología,
Hígado/efectos de los fármacos,
Hígado/ultraestructura,
Riñón/efectos de los fármacos,
Riñón/ultraestructura,
Corazón/efectos de los fármacos,
Miocardio/ultraestructura,
Sistema Enzimático del Citocromo P-450/análisis,
Citocromos b5/análisis,
Ratas Wistar,
Microscopía,
Antineoplásicos Fitogénicos
Objective: To determine the impact of COVID-19 on vitamin E concentrations and oxidative stress in patients affected by the disease. Method: We conducted a systematic review using observational studies published between 2020 and 2023, which addressed the impact of COVID-19 on vitamin E concentrations and...
SUMMARY: The toxic effects of acetaminophen appear primarily in the liver and kidney. The protective effect of blue green alga Arthrospira platensis on hepato-renal toxicity caused by acetaminophen was evaluated in male rats. The obtained results showed that subcutaneous injection of acetaminophen at a d...
Hígado/efectos de los fármacos,
Riñón/efectos de los fármacos,
Acetaminofén/toxicidad,
Spirulina,
Preparaciones de Plantas/administración & dosificación,
Peroxidación de Lípido,
Alanina Transaminasa/análisis,
Fosfatasa Alcalina/análisis,
Aspartato Aminotransferasas/análisis,
Interleucinas,
Ratas Wistar,
Superóxido Dismutasa
Bosanac, Milana;
Amidzic, Jelena;
Stefanovic, Maja;
Radic, Jelena;
Kolarov-Bjelobrk, Ivana;
Janicic, Stefan;
Gojkovic, Zdenka;
Lazic, Bojana;
Djokanovic, Dejan;
Misan, Aleksandra;
Cvetkovic, Biljana;
Stupar, Alena;
Martic, Nikola;
Andrejic-Visnjic, Bojana.
SUMMARY: Doxorubicin (DOX) is one of the drugs necessary for the treatment of the 10 most common types of cancer. The leading adverse effect limiting clinical use of DOX is cardiotoxicity. Given that literature data indicate a protective role of carotenoids in doxorubicin-induced toxicity, in our study w...
Cardiotoxicidad/prevención & control,
Cucurbita/química,
Carotenoides/administración & dosificación,
Doxorrubicina/toxicidad,
Antibióticos Antineoplásicos/toxicidad,
Neoplasias/tratamiento farmacológico,
Peroxidación de Lípido,
Catalasa,
Glutatión Transferasa,
Glutatión Peroxidasa,
Ratas Wistar,
Antioxidantes,
Estrés Oxidativo/efectos de los fármacos,
Cardiotónicos
Acetylcholinesterase (AChE), hydrolyzes acetylcholine to choline and acetate, thereby terminating this neurotransmitter effect at cholinergic synapses. Therefore, AChE inhibition is used for counterbalance the cholinergic deficit in Alzheimer’s disease (AD) patients. In the ...
Inhibidores de la Colinesterasa/farmacología,
Flavonoides/análisis,
Enfermedad de Alzheimer/tratamiento farmacológico,
Marruecos,
Fenoles/análisis,
Peroxidación de Lípido/efectos de los fármacos,
Antioxidantes/farmacología,
Rumex,
Taraxacum,
Hypericum,
Inhibidores de la Colinesterasa/química,
Antioxidantes/química,
Especies Reactivas de Oxígeno
Hussain, S A;
Abbas, S R;
Sabir, S M;
Khan, R T;
Ali, S;
Nafees, M A;
Khan, S W;
Hussain, A;
Abbas, Q;
Ali, M;
Bukhari, S A E.
Abstract The present study was aimed to evaluate the antioxidant potential and inhibitory effect ofCannabis sativa and Morus nigra against lipid peroxidation in goat brain and liver homogenates. The formation of free radicals, highly reactive oxygen species (ROS) and reactive nitrogen species (RNS) is a ...
La peroxidación lipídica es un proceso complejo que hace referencia a la degradación oxidativa de los lípidos, a través del cual los radicales libres capturan electrones de los lípidos en las membranas celulares, lo cual compromete la integridad y la función de la membrana. Mediante una serie de ...
Canine Distemper is a disease caused by Canine morbillivirus (CM), a pantropic virus that can affect the central nervous system (CNS), causing demyelination. However, the pathogenesis of this lesion remains to be clarified. Brain samples of 14 naturally infected dogs by CM were analyzed to evaluate the p...
Moquillo/diagnóstico,
Perros/virología,
Infecciones del Sistema Nervioso Central/veterinaria,
Cerebro/virología,
Biomarcadores/metabolismo,
Peroxidación de Lípido/efectos de los fármacos,
Estrés Oxidativo/fisiología,
Enfermedades Desmielinizantes/veterinaria,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa/instrumentación,
Inmunohistoquímica/instrumentación,
Morbillivirus/patogenicidad
Cardiovascular disease(CVD) remains the major cause of mortality in the world, typically claiming a third of all deaths. The primary cause of CVD is atherosclerosis. Therefore, timely prevention and therapy of atherosclerosis are able to reduce the risk of the development of its clinical manif...
Aterosclerosis/dietoterapia,
Dieta Aterogénica/métodos,
Aceite de Oliva/farmacología,
Colesterol/farmacología,
Dieta Alta en Grasa/métodos,
Estrés Oxidativo/inmunología,
Glutatión/farmacología,
Peroxidación de Lípido/inmunología,
Triglicéridos/farmacología,
Hipercolesterolemia/inmunología,
Lipoproteínas/inmunología,
Ratas Wistar/inmunología
