LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Hepatic toxicity caused by PLGA-microspheres containing usnic acid from the lichen C ladonia substellata (AHTI) during pregnancy in Wistar rats

MARINHO, KETSIA S N; ANTONIO, ERIVALDO A; SILVA, CAMILLA V N S; SILVA, KEILA T DA; TEIXEIRA, VALÉRIA W; AGUIAR JUNIOR, FRANCISCO C A DE; SANTOS, KATHARINE R P DOS; SILVA, NICÁCIO H DA; SANTOS, NOEMIA P S.

An. acad. bras. ciênc; 89 (2), 2017

ABSTRACT This study aimed to evaluate the teratogenic and hepatotoxic potential of the usnic acid encapsulated into PLGA-microspheres. In total, 12 female Wistar rats in pregnancy were randomly distributed in the control group (n= 6) that received 1.0 mL of physiological solution and treatment group (n= ...

Anomalías Inducidas por Medicamentos, Ascomicetos/química, Benzofuranos/química, Benzofuranos/toxicidad, Peso Fetal/efectos de los fármacos, Feto/efectos de los fármacos, Hepatocitos/efectos de los fármacos, Ácido Láctico/química, Ácido Láctico/toxicidad, Líquenes/química, Hígado/efectos de los fármacos, Hígado/patología, Exposición Materna, Ácido Poliglicólico/química, Ácido Poliglicólico/toxicidad, Copolímero de Ácido Poliláctico-Ácido Poliglicólico, Distribución Aleatoria, Ratas Wistar, Valores de Referencia

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Effects of Aspartame on Maternal-Fetal and Placental Weights, Length of Umbilical Cord and Fetal Liver: A Kariometric Experimental Study

Aspartame is a synthetic sweetener consumed by more than half the adult population in 75 countries. Their metabolites can be toxic, principally to the liver and retina, and there are few studies on the use of aspartame in gestation. Twenty pregnant rats were weighed and allocated randomly (n=5 per group)...