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Nicotinamide activates latent HIV-1 ex vivo in ART suppressed individuals, revealing higher potency than the association of two methyltransferase inhibitors, chaetocin and BIX01294

Samer, Sadia; Arif, Muhammad Shoaib; Giron, Leila Bertoni; Zukurov, Jean Paulo Lopes; Hunter, James; Santillo, Bruna Teresa; Namiyama, Gislene; Galinskas, Juliana; Komninakis, Shirley Vasconcelos; Oshiro, Telma Miyuki; Sucupira, Maria Cecilia; Janini, Luiz Mario; Diaz, Ricardo Sobhie.
Braz. j. infect. dis; 24 (2), 2020
ABSTRACT Background: Latent HIV-1 is a major hurdle in obtaining HIV-1 sustained virological remission (SVR). Here we explored histone deacetylation inhibition property of nicotinamide (NAM; n = 17) for the first time in comparison to a combination of methyltransferase inhibitors (MTIs; Chaetocin and BI...
Azepinas/farmacología, Infecciones por VIH/virología, VIH-1/efectos de los fármacos, Metiltransferasas/antagonistas & inhibidores, Niacinamida/farmacología, Quinazolinas/farmacología, Activación Viral/efectos de los fármacos, Linfocitos T CD4-Positivos, Regulación Viral de la Expresión Génica, Leucocitos Mononucleares/virología, Piperazinas/farmacología, Carga Viral/efectos de los fármacos, Tropismo Viral/efectos de los fármacos, Latencia del Virus
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Influence of sildenafil and buflomedil on survival of randomized flaps in rats: an experimental study

Figueiredo, Jason C. Abrantes; Zampar, Antonio Gustavo; Destro, Cristina; Arias, Victor Eduardo A; Morro, Rebeca; Pinheiro, Adivânia de Souza; Mélega, José Marcos de Andrade.
Rev. bras. cir. plást; 26 (3), 2011
BACKGROUND: Microcirculation dysfunction, as a consequence of localized vascular insufficiency, is considered to be one of the dominant causes of surgical flap necrosis. Several vasoactive drugs have been tested for the pharmacological treatment of tissue ischemia, with varying degrees of success. This s...
Vasodilatadores, Vasodilatadores/farmacología, Vasodilatadores/uso terapéutico, Colgajos Quirúrgicos, Colgajos Quirúrgicos/cirugía, Piperazinas, Piperazinas/farmacología, Pirrolidinas, Pirrolidinas/farmacología, Piperazinas/uso terapéutico, Pirrolidinas/uso terapéutico, Necrosis, Necrosis/prevención & control, Ratas, Ratas/anatomía & histología, Dorso, Distribución Aleatoria
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