LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

The NK1 receptor antagonist NKP608 inhibits proliferation of human colorectal cancer cells via Wnt signaling pathway

Niu, Xiao-Ling; Hou, Jian-Feng; Li, Jing-Xiang.

Biol. Res; 51 (), 2018

BACKGROUND: Neurokinin1 (NK1) receptor has played a vital role in the development of tumor. However, NKP608 as a NK1 receptor antagonist whether has the effect of the resistance of colorectal cancer is still unclear. Thereby, in this study, we investigated the role of NKP608 on human colorectal cancer an...

Movimiento Celular/efectos de los fármacos, Proliferación Celular/efectos de los fármacos, Neoplasias Colorrectales/patología, Antagonistas del Receptor de Neuroquinina-1/farmacología, Piperidinas/farmacología, Quinolinas/farmacología, Vía de Señalización Wnt/efectos de los fármacos, Regulación hacia Abajo/efectos de los fármacos, Western Blotting, Línea Celular Tumoral, Citometría de Flujo, Células HCT116

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Rimonabant improves metabolic parameters partially attributed to restoration of high voltage-activated Ca2+ channels in skeletal muscle in HFD-fed mice

Chen, B; Hu, N.

Braz. j. med. biol. res; 50 (6), 2017

Cannabinoid type 1 receptor (CB1R) inhibition tends to be one of the promising strategies for the treatment of obesity and other related metabolic disorders. Although CB1R inhibition may cause adverse psychiatric effects including depression and anxiety, the investigation of the role of peripheral CB1R o...

Glucemia/efectos de los fármacos, Peso Corporal/efectos de los fármacos, Canales de Calcio/efectos de los fármacos, Canales de Calcio/metabolismo, Canales de Calcio Tipo L/efectos de los fármacos, Canales de Calcio Tipo L/metabolismo, Antagonistas de Receptores de Cannabinoides/farmacología, Dieta Alta en Grasa/efectos adversos, Intolerancia a la Glucosa/etiología, Resistencia a la Insulina, Ratones Endogámicos C57BL, Modelos Animales, Músculo Esquelético/efectos de los fármacos, Músculo Esquelético/metabolismo, Obesidad/etiología, Piperidinas/farmacología, Pirazoles/farmacología, Receptor Cannabinoide CB1/antagonistas & inhibidores, Receptor Cannabinoide CB1/fisiología

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Repaglinide and prandial glucose regulation: the rational approach to therapy in Type 2 diabetes?

Frandesen, Brown Kirstine; Tambasca, Marcos A.

Arq. bras. endocrinol. metab; 43 (5), 1999

This article reviews the clinical evidence and pharmacological rotionale for repaglinide, a prandial glucose regular. Repaglinide has a rapid onset and short duration action - a pharmacokinetic profile that allows administration in a flexible schedule at mealttimes to limit the postprandial blood glucose...

Glucosa/metabolismo, Piperidinas/farmacología, Hiperglucemia/metabolismo, Insulina/sangre, Piperidinas/uso terapéutico, Oncogenes, Glucemia/efectos de los fármacos

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