Abstract Vitiligo is a disease that causes macules and achromic and/or hypochromic patches, which can affect from small areas to the entire tegument. Treatment options are few and are generally ineffective. Recently, some case reports have appeared which show positive results with the use of Janus kinase...
Biological therapy dramatically changed the management of Ulcerative Colitis (UC). However, a significant number of these patients fail to respond or have secondary loss of response to this strategy. In this clinical situation, the options include intensification of anti-TNF therapy, the use of a second ...
ABSTRACT Janus kinases inhibitors have already been incorporated into the management of immune-mediated diseases, such as rheumatoid arthritis, and are being investigated for the treatment of psoriasis and inflammatory bowel diseases, both ulcerative colitis and Crohn's disease. Tofacitinib is an oral sm...
ABSTRACT Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor originating from parafollicular C cells of the thyroid and associated with mutations in the proto-oncogene REarranged during Transfection (RET). The prognosis of MTC depends on clinical stage, with a 95.6% 10-year survival rate amo...
Anilidas/efectos adversos,
Anilidas/uso terapéutico,
Carcinoma Neuroendocrino/tratamiento farmacológico,
Carcinoma Neuroendocrino/metabolismo,
Piperidinas/efectos adversos,
Piperidinas/uso terapéutico,
Inhibidores de Proteínas Quinasas/efectos adversos,
Inhibidores de Proteínas Quinasas/uso terapéutico,
Piridinas/efectos adversos,
Piridinas/uso terapéutico,
Quinazolinas/efectos adversos,
Quinazolinas/uso terapéutico,
Medición de Riesgo,
Neoplasias de la Tiroides/tratamiento farmacológico,
Neoplasias de la Tiroides/metabolismo
Mota, Licia Maria Henrique da;
Cruz, Bóris Afonso;
Albuquerque, Cleandro Pires de;
Gonçalves, Deborah Pereira;
Laurindo, Ieda Maria Magalhães;
Pereira, Ivanio Alves;
Carvalho, Jozélio Freire de;
Pinheiro, Geraldo da Rocha Castelar;
Bertolo, Manoel Barros;
Pinto, Maria Raquel da Costa;
Louzada-Junior, Paulo;
Xavier, Ricardo Machado;
Giorgi, Rina Dalva Neubarth;
Lima, Rodrigo Aires Corrêa.
Resumo Em 2014, o tofacitinibe, um medicamento modificador do curso da doença (MMCD) sintético, alvo-específico, inibidor seletivo das Janus quinases (JAK), foi aprovado para uso no Brasil. Este documento de posicionamento tem o objetivo de atualizar as recomendações da Sociedade Brasileira de Reuma...
Antirreumáticos/uso terapéutico,
Artritis Reumatoide/tratamiento farmacológico,
Brasil,
Quimioterapia Combinada,
Metotrexato/uso terapéutico,
Piperidinas/uso terapéutico,
Pirimidinas/uso terapéutico,
Pirroles/uso terapéutico,
Reumatología,
Sociedades Médicas,
Insuficiencia del Tratamiento
Medullary thyroid carcinoma (MTC) may rarely present with paraneoplastic syndromes. Among the most frequent ones are the appearance of diarrhea and ectopic Cushing syndrome (ECS). The ECS in the context of MTC is usually present in patients with distant metastatic disease. The use of drugs such as ketoco...
Carcinoma Neuroendocrino/complicaciones,
Carcinoma Neuroendocrino/tratamiento farmacológico,
Síndrome de Cushing/tratamiento farmacológico,
Síndrome de Cushing/etiología,
Progresión de la Enfermedad,
Estadificación de Neoplasias,
Piperidinas/uso terapéutico,
Quinazolinas/uso terapéutico,
Neoplasias de la Tiroides/complicaciones,
Neoplasias de la Tiroides/tratamiento farmacológico,
Resultado del Tratamiento
OBJETIVO: Revisar os principais avanços no potencial uso terapêutico de alguns compostos canabinoides em psiquiatria. MÉTODO: Foi realizada busca nos bancos de dado PubMed, SciELO e Lilacs e identificados estudos e revisões da literatura sobre o uso terapêutico dos canabinoides em psiquiatria, em pa...
This article reviews the clinical evidence and pharmacological rotionale for repaglinide, a prandial glucose regular. Repaglinide has a rapid onset and short duration action - a pharmacokinetic profile that allows administration in a flexible schedule at mealttimes to limit the postprandial blood glucose...
