Stable expression of Mycobacterium bovis antigen 85B in auxotrophic M. bovis bacillus Calmette-Guérin
Mem. Inst. Oswaldo Cruz; 112 (2), 2017
BACKGROUND Bovine tuberculosis (TB) is a zoonotic disease caused by Mycobacterium bovis, responsible for causing major losses in livestock. A cost effective alternative to control the disease could be herd vaccination. The bacillus Calmette-Guérin (BCG) vaccine has a limited efficacy against bovine TB,...
Antígenos Bacterianos/inmunología, Antígenos Bacterianos/metabolismo, Vacuna BCG/genética, Vacuna BCG/inmunología, Escherichia coli/genética, Vectores Genéticos, Vectores Genéticos/inmunología, Ratones Endogámicos BALB C, Mycobacterium bovis/genética, Mycobacterium bovis/inmunología, Plásmidos/genética, Plásmidos/inmunología