LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Acteoside Attenuates Recognition Memory Impairment in CUMS Rats via Regulating Synaptic Plasticity and mTOR Signaling Pathway

Sun, Manli; Fan, Wenjuan; Wang, Xinghong; Meng, Jin; Zhang, Fuhua; Chang, Quanzhong; Deng, Haifeng.

Int. j. morphol; 42 (2), 2024

SUMMARY: We evaluated the role and mechanism of acteoside in the regulation of memory impairment induced by chronic unpredictable mild stress (CUMS). CUMS was used to induce depression in rats and the successful establishment of CUMS model were verified by forced swimming test and sucrose preference test...

Estrés Psicológico/complicaciones, Trastornos de la Memoria/tratamiento farmacológico, Glucósidos/administración & dosificación, Glucósidos/uso terapéutico, Polifenoles/administración & dosificación, Polifenoles/uso terapéutico, Reconocimiento en Psicología/efectos de los fármacos, Plasticidad Neuronal/efectos de los fármacos, Serina-Treonina Quinasas TOR/antagonistas & inhibidores, Depresión/tratamiento farmacológico, Modelos Animales de Enfermedad, Ratas Sprague-Dawley, Escala de Evaluación de la Conducta, Neuronas, Técnica del Anticuerpo Fluorescente, Western Blotting, Aprendizaje por Laberinto, Inhibidores mTOR

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Effects of Beta; 1-adrenoceptors in the Basolateral Amygdala on Spatial Memory, Passive Avoidance, Long-term Potentiation and Neuronal Arborization in the Hippocampal CA1 Region in Response to Unavoidable Stress

Hosseinmardi, Leila; Meftahi, Gholam Hossein; Shiravi, Abdolhossein; Shirvani, Hossein; Sharafi, Shahram.

Braz. arch. biol. technol; 63 (), 2020

Abstract Norepinephrine in the basolateral amygdala (BLA) plays a pivotal role in mediating the effects of stress on memory functions in the hippocampus, however, the functional contribution of β1-adrenergic receptors on the BLA inputs to the CA1 region of hippocampus and memory function are not wel...

Norepinefrina/metabolismo, Región CA1 Hipocampal/efectos de los fármacos, Agonistas de Receptores Adrenérgicos beta 1/farmacología, Plasticidad Neuronal/efectos de los fármacos, Hipocampo/efectos de los fármacos, Estrés Fisiológico/efectos de los fármacos, Complejo Nuclear Basolateral/efectos de los fármacos, Ratas Endogámicas BB, Dobutamina/farmacología

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Serotonin induces or inhibits neuritic regeneration of leech CNS neurons depending on neuronal identity

Vargas, J; Alfaro-Rodríguez, A; Perez-Orive, J.

Braz. j. med. biol. res; 52 (2), 2019

Recovery of motor function after central nervous system (CNS) injury is dependent on the regeneration capacity of the nervous system, which is a multifactorial process influenced, among other things, by the role of neuromodulators such as serotonin. The neurotransmitter serotonin can promote neuronal reg...

Sistema Nervioso Central/citología, Concanavalina A/farmacología, Sanguijuelas/efectos de los fármacos, Neuronas Motoras/efectos de los fármacos, Regeneración Nerviosa/efectos de los fármacos, Neuritas/efectos de los fármacos, Plasticidad Neuronal/efectos de los fármacos, Serotonina/farmacología

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Effect of intra-hippocampal injection of human recombinant growth hormone on synaptic plasticity in the nucleus basalis magnocellularis-lesioned aged rats

Malek, Maryam; Sarkaki, Alireza; Zahedi-Asl, Saleh; Farbood, Yaghoob; Rajaei, Ziba.

Arq. neuropsiquiatr; 75 (7), 2017

ABSTRACT In this study, we proposed that administration of hippocampal growth hormone in ageing animals with growth hormone deficiency can compensate long-term potentiation and synaptic plasticity in nucleus basalis magnocellularis (NBM)-lesioned rats. Aged male Wistar rats were randomly divided into six...

Núcleo Basal de Meynert/efectos de los fármacos, Núcleo Basal de Meynert/fisiología, Hormona del Crecimiento/farmacología, Hipocampo/efectos de los fármacos, Hipocampo/fisiología, Modelos Animales, Plasticidad Neuronal/efectos de los fármacos, Plasticidad Neuronal/fisiología, Ratas Wistar, Factores de Tiempo

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