LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Decreased plasmatic spermidine and increased spermine in mild cognitive impairment and Alzheimer's disease patients

JOAQUIM, HELENA P. G; COSTA, ALANA C; FORLENZA, ORESTES V; GATTAZ, WAGNER F; TALIB, LEDA L.

Arch. Clin. Psychiatry (Impr.); 46 (5), 2019

Abstract Background Current evidence suggests that upregulation of polyamines system plays a role both in cognitive deficit and synaptic loss observed in Alzheimer's disease (AD). Objective The aim of this study was to determine the plasmatic concentration of polyamines in mild cognitive impairment (...

Poliaminas/sangre, Disfunción Cognitiva/fisiopatología, Enfermedad de Alzheimer/fisiopatología, Cromatografía Liquida/métodos, Espectrometría de Masas en Tándem/métodos, Biomarcadores/sangre, Espermina/sangre, Metabolómica/métodos, Poliaminas/metabolismo, Enfermedad de Alzheimer/diagnóstico, Disfunción Cognitiva/diagnóstico, Espermidina/sangre, Ornitina/sangre, Putrescina/sangre

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Characterization of OAZ1 and its potential functions in goose follicular development

Background: Ornithine decarboxylase antizyme 1 (OAZ1) is an important regulator of polyamine synthesis and uptake. Our previous studies indicated that high OAZ1 expression in the ovaries of laying geese is responsible for poor egg production. In the present study, the molecular characterization of goose ...