Protein PEGylation for the design of biobetters: from reaction to purification processes
Braz. J. Pharm. Sci. (Online); 54 (spe), 2018
The covalent attachment of polyethylene glycol (PEG) to therapeutical proteins is an important route to develop biobetters for biomedical, biotech and pharmaceutical industries. PEG conjugation can shield antigenic epitopes of the protein, reduce degradation by proteolytic enzymes, enhance long-term stab...