LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Effect of carrier materials on the properties of the andrographolide solid dispersion

Zhang, Shoude; Zeng, Qingyun; Zhao, Guowei; Dong, Wei; Ou, Liquan; Cai, Ping; Liao, Zhenggen; Liang, Xinli.

Braz. J. Pharm. Sci. (Online); 58 (), 2022

Abstract In the work the andrographolide (AG)-solid dispersions (SDs) were prepared by the spray-drying method, using polyethylene glycol 8000 (PEG8000), Poloxamer188, polyvinylpyrrolidone K30 (PVPK30), Soluplus® as carrier materials. The effect of different polymers as carrier materials on the properti...

Secado por Pulverización, Disolución, Métodos, Polietilenglicoles/efectos adversos, Polímeros/análisis, Preparaciones Farmacéuticas/análisis, Agua

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Assessment of tolerance and acceptability between mannitol solution and polyethylene glycol as bowel preparation for colonoscopy: a three-center study

Piñerúa-Gonsálvez, Jean Félix; Zambrano-Infantino, Rosanna del Carmen; Baptista, Alberto; Sulbaran, Mariseli; Camaray, Noheltriz.

Rev. gastroenterol. Perú; 40 (1), 2020

ABSTRACT Introduction: Adequate bowel preparation is one of the most important factors related to the yield of colonoscopy. Low quality bowel preparation has been associated with lower adenoma detection rates and increased healthcare expenses. Bowel preparation is a major impediment to undergo colonosc...

Catárticos/efectos adversos, Colonoscopía, Manitol/efectos adversos, Satisfacción del Paciente/estadística & datos numéricos, Polietilenglicoles/efectos adversos, Catárticos/administración & dosificación, Estudios Transversales, Manitol/administración & dosificación, Evaluación de Resultado en la Atención de Salud, Polietilenglicoles/administración & dosificación, Estudios Prospectivos

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PEGylation strategy to the development of analytical and therapeutic proteins

Santos, João Henrique Picado Madalena.

Protein PEGylation is the covalent bonding of polyethylene glycol (PEG) polymers to amino acid residues of the protein and it is one of the most promising techniques for improving the therapeutic effect of biopharmaceuticals and long-term stability of protein-based biosensors. This chemical modification ...

Proteínas/análisis, Polietilenglicoles/efectos adversos, Productos Biológicos/uso terapéutico, Proteínas/aislamiento & purificación, Citocromos c

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First-wave protease inhibitors for hepatitis C genotype 1 treatment: a real-life experience in Brazilian patients

Chachá, Silvana Gama Florencio; Rodrigues, João Paulo Vilela; Araújo, Roberta Chaves; Pereira, Leonardo Régis Leira; Villanova, Márcia Guimarães; Souza, Fernanda Fernandes; Santana, Rodrigo de Carvalho; Martinelli, Ana de Lourdes Candolo.

Rev. Soc. Bras. Med. Trop; 51 (2), 2018

Abstract INTRODUCTION: Licensed for chronic hepatitis C treatment in 2011, the protease inhibitors (PIs) telaprevir (TVR) and boceprevir (BOC), which have high sustained viral responses (SVR), ushered a new era characterized by the development of direct-action drugs against the hepatitis C virus (HCV). ...

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Tolerancia, seguridad y eficacia de la preparación intestinal con un día de PEG3350 + bisacodilo en comparación con 2 días de PEG3350 + bisacodilo en pacientes pediátricos

Portillo Canizalez, Ligia Marcela; Blanco Rodriguez, Gerardo; Teyssier Morales, Gustavo; Penchyna Grub, Jaime; Trauernicht Mendieta, Sean; Zurita-Cruz, Jessie Nallely.

Bol. méd. Hosp. Infant. Méx; 74 (5), 2017

Resumen: Introducción: Múltiples preparaciones intestinales se han utilizado en niños sometidos a una colonoscopia, con limitación variable debido a la aceptación, tolerancia y la limpieza adecuada. El objetivo del estudio fue comparar la tolerancia seguridad y eficacia de la preparación intestin...

Bisacodilo/administración & dosificación, Catárticos/administración & dosificación, ColonoscopíaMétodos, Polietilenglicoles/administración & dosificación, Bisacodilo/efectos adversos, Catárticos/efectos adversos, Esquema de Medicación, Quimioterapia Combinada, Cumplimiento de la Medicación, Aceptación de la Atención de Salud, Polietilenglicoles/efectos adversos, Encuestas y Cuestionarios

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PEG-asparaginase induced severe hypertriglyceridemia

Galindo, Rodolfo J; Yoon, Justin; Devoe, Craig; Myers, Alyson K.

Arch. endocrinol. metab. (Online); 60 (2), 2016

Asparaginase (ASP) is an effective chemotherapy agent extensively used in children with acute lymphocytic leukemia (ALL). There has been a recent interest in using ASP in adults with ALL, particularly the less toxic pegylated (PEG) formulation. Hypertriglyceridemia (HTG) is a rare complication of PEG-ASP...

Antineoplásicos/efectos adversos, Asparaginasa/efectos adversos, Complicaciones de la Diabetes, Progresión de la Enfermedad, Hipertrigliceridemia/inducido químicamente, Obesidad/congénito, Polietilenglicoles/efectos adversos, Factores de Riesgo, Triglicéridos/sangre

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Depressive episode incidence in patients with chronic hepatitis c treated with pegylated interferon and ribavirin

Vabo, Izabella Liguori Corsino; Ferreira, Lincoln Eduardo Villela Vieira de Castro; Pace, Fábio Heleno Lima.

Arq. gastroenterol; 53 (1), 2016

ABSTRACT Background The effectiveness of antiviral therapy with pegylated interferon and ribavirin for chronic hepatitis C is far from ideal and presents several adverse events. Among such events, there is the depressive episode that can even lead to treatment discontinuity Objective Analyze the incide...

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