LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Doxycycline release and antibacterial activity from PMMA/PEO electrospun fiber mats

Carvalho, Luana Dutra de; Peres, Bernardo Urbanetto; Maezono, Hazuki; Shen, Ya; Haapasalo, Markus; Jackson, John; Carvalho, Ricardo M; Manso, Adriana P.

J. appl. oral sci; 27 (), 2019

Abstract Objective: To investigate the use of polymethyl methacrylate (PMMA) electrospun fiber mats containing different amounts of polyethylene oxide (PEO) as a doxycycline delivery system and to test antibacterial activity against an oral pathogen. Methodology: PMMA powders or PEO (mol wt 200 Kd) (10...

Análisis de Varianza, Antibacterianos/química, Antibacterianos/farmacocinética, Cromatografía Líquida de Alta Presión/métodos, Doxiciclina/química, Doxiciclina/farmacocinética, Inmersión, Microscopía Electrónica de Rastreo, Peso Molecular, Nanofibras/química, Polietilenglicoles/química, Polietilenglicoles/farmacocinética, Polimetil Metacrilato/química, Polimetil Metacrilato/farmacocinética, Reproducibilidad de los Resultados, Streptococcus mutans/efectos de los fármacos, Factores de Tiempo, Agua/química

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Comparative study of the stability of free and modified papain incorporated in topical formulations

Papain is an enzyme used in topical formulations as a proteolytic debriding agent for the treatment of open, extensive wounds and burnings. It is also employed as an enhancer for cutaneous permeation of active compounds, chemical peeling and as a progressive depilatory agent. The stability of formulation...