Multiple antibiotic susceptibility of polyphosphate kinase mutants (ppk1 and ppk2) from Pseudomonas aeruginosa PAO1 as revealed by global phenotypic analysis
Biol. Res; 48 (), 2015
BACKGROUND: Pseudomonas aeruginosa is known to be a multidrug resistant opportunistic pathogen. Particularly, P. aeruginosa PAO1 polyphosphate kinase mutant (ppk1) is deficient in motility, quorum sensing, biofilm formation and virulence. FINDINGS: By using Phenotypic Microarrays (PM) we analyzed near 20...
Farmacorresistencia Bacteriana Múltiple/genética, Análisis por Micromatrices/métodos, Fosfotransferasas (Aceptor del Grupo Fosfato)/genética, Pseudomonas aeruginosa/enzimología, Antibacterianos/farmacología, Cloranfenicol/farmacología, Ciprofloxacina/farmacología, Polifosfatos/metabolismo, Pseudomonas aeruginosa/efectos de los fármacos, Pseudomonas aeruginosa/patogenicidad, Rifampin/farmacología, Virulencia/genética, Mutación, Fenotipo