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Pullulan as a stabilizer agent of polymeric nanocapsules for drug delivery

Chassot, Janaíne Micheli; Ferreira, Luana Mota; Gomes, Felipe Pereira; Silva, Cristiane de Bona da; Tasso, Leandro; Cruz, Letícia.
Braz. j. pharm. sci; 52 (4), 2016
ABSTRACT Polymeric stabilizers have received attention in the preparation of nanostructured systems due to their ability to enhance formulation stability. Considering this, the objective of this work was to prepare poly(ε-caprolactone) nanocapsules using the pullulan as a polymeric stabilizer. The n...
Polisacáridos/clasificación, Productos Biológicos/clasificación, Nanocápsulas/22074, Difusión, Sistemas de Liberación de Medicamentos, Excipientes
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Pullulan: an advantageous natural polysaccharide excipient to formulate tablets of alendronate-loaded microparticles

Ferreira, Luana Mota; Velasquez, Aline de Arce; Schaffazick, Scheila Rezende; Cruz, Letícia.
Braz. j. pharm. sci; 51 (1), 2015
This work reports the preparation of tablets by direct compression of sodium alendronate-loaded microparticles, using pullulan as filler. The tableting properties of pullulan were compared with those of microcrystalline cellulose and lactose. Pullulan tablets showed low variations in average weight, thic...
Polisacáridos/clasificación, Comprimidos/farmacocinética, Alendronato/farmacocinética, Excipientes/clasificación, Trituración de Residuos Sólidos
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