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Cytotoxicity of hydroxydihydrobovolide and its pharmacokinetic studies in Portulaca oleracea L. extract

Xu, Liang; Tao, Xiaojun; Gao, Yucong; Zhang, Wenjie; Meng, Yihan; Li, Cuiyu; Jiang, Mingyue; Xixiang, Ying.
Braz. J. Pharm. Sci. (Online); 53 (2), 2017
ABSTRACT Hydroxydihydrobovolide (HDB) was for the first time isolated from Portulaca oleracea L. and then its cytotoxicity against SH-SYTY cells was studied. Moreover, a rapid and sensitive ultra-high performance liquid chromatographic (UHPLC) method with bergapten as internal standard (IS) was developed...
Cromatografía Líquida de Alta Presión/métodos, Portulaca/clasificación, Extractos Vegetales/análisis, Farmacocinética
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Tissue distribution and excretion of the five components of Portulaca oleracea L. extract in rat assessed by UHPLC

Zhang, Wenjie; Li, Di; Leng, Aijing; Ai, Junjun; Du, Yang; Meng, Yihan; Gao, Yucong; Ying, Xixiang.
Braz. j. pharm. sci; 51 (3), 2015
The aim of the present study was to investigate the tissue distribution and excretion of five components of Portulaca oleracea L. extract (POE) in rat following oral administration. A rapid, sensitive and specific ultra-high performance liquid chromatography (UHPLC) method with puerarin as the internal s...
Portulaca/clasificación, Cromatografía Liquida/22074, Ratas, Compuestos Fenólicos, Distribución Tisular
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HPLC method for the simultaneous determination of four compounds in rat plasma after intravenous administration of Portulaca oleracea L. extract

Cheng, Zhongzhe; Xie, Ming; Zhang, Wenjie; Cheng, Lan; Du, Yang; Wang, Yunjiao; Ying, Xixiang; Kang, Tingguo.
Braz. j. pharm. sci; 48 (1), 2012
The objective of the present study was to develop a simple and selective HPLC method for the simultaneous determination of hesperidin (HP), caffeic acid (CA), ferulic acid (FA) and p-coumaric acid (p-CA) in rat plasma after intravenous administration of Portulaca oleracea L. extract (POE). With the hyper...
Cromatografía Líquida de Alta Presión/métodos, Ratas/clasificación, Administración Intravenosa/22074, Portulaca/clasificación, Farmacocinética, Plantas Medicinales/metabolismo
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