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Enriched environment alleviates post-stroke cognitive impairment through enhancing α7-nAChR expression in rats

Yuan, Mei; Zhang, Xin-Xin; Fu, Xiao-Cui; Bi, Xia.
Arq. neuropsiquiatr; 78 (10), 2020
ABSTRACT Background: Enriched environment (EE) is a simple and effective intervention to improve cognitive function in post-stroke cognitive impairment (PSCI), partly due to the rebalancing of the cholinergic signaling pathway in the hippocampus. α7-nicotinic acetylcholine receptor (α7-nAChR)...
Disfunción Cognitiva, Ambiente, Potenciación a Largo Plazo/fisiología, Accidente Cerebrovascular, Receptor Nicotínico de Acetilcolina alfa 7/química, Receptor Nicotínico de Acetilcolina alfa 7/fisiología
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Preoperative anxiety induces chronic postoperative pain by activating astrocytes in the anterior cingulate cortex region

Gu, Damin; Zhou, Minmin; Han, Chao; Lei, Daoyun; Xie, Songhui; Yuan, Yanbo; Ma, Tieliang.
Rev. Assoc. Med. Bras. (1992, Impr.); 65 (9), 2019
SUMMARY OBJECTIVE The study aims to explore the relationship between preoperative anxiety and chronic postoperative pain. METHODS A total of forty rats were divided into four groups, control, single-prolonged stress alone, Hysterectomy alone, and SPS+ Hysterectomy. The paw withdrawal mechanical thres...
Ansiedad/complicaciones, Astrocitos/metabolismo, Dolor Crónico/etiología, Dolor Crónico/psicología, Modelos Animales de Enfermedad, Proteína Ácida Fibrilar de la Glía/metabolismo, Giro del Cíngulo/metabolismo, Miembro Posterior, Histerectomía, Potenciación a Largo Plazo/fisiología, Umbral del Dolor/fisiología, Dolor Postoperatorio/etiología, Dolor Postoperatorio/psicología, Periodo Preoperatorio, Distribución Aleatoria, Ratas Sprague-Dawley, Estrés Psicológico/etiología, Factores de Tiempo
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