Results: 272

Direct spectrofluorimetric methods as alternatives to compendial ones used for the quality control of biopharmaceuticals: development, validation and application

Abstract A simple, rapid, precise, accurate and sustainable spectrofluorimetric method (SFM) was developed, validated and applied for the determination of 4-aminobenzoic acid and aromatic amino acids (phenylalanine, tryptophan and tyrosine). These compounds are used in biopharmaceutical formulations and ...

Quimioprospecção de cianobactérias brasileiras utilizando metabolômica e ensaios biológicos
Chemoprospecting of Brazilian cyanobacteria using metabolomics and biological assays

Os produtos naturais são uma importante fonte de moléculas com aplicações terapêuticas e biotecnológicas. No entanto, a complexidade inerente às matrizes biológicas e as crescentes taxas de redescoberta de moléculas impõem desafios para a busca por novos compostos bioativos. A exploração de n...

Alternative products in tropical treatment of radiation induced xerostomia: a systematic review

Xerostomia, a term used to characterize the sensation of dry mouth, it is one of the most common symptoms after radiotherapy treatment of the head and neck region, being also the most expensive, impacting the oral health and quality of life of these patients. We performed a systematic review to identify ...

Orientações quanto à sistemática de comunicação de recoleta/rejeição/incidente de amostras biológicas pelos laboratórios municipais (Sudeste, Lapa, São Miguel, Santo Amaro e Nossa Senhora do Ó) às Unidades Básicas de Saúde, às Supervisões Técnicas e às Coordenadorias de Saúde
Guidelines on the system for reporting re-collection/rejection/incident of biological samples by municipal laboratories (Sudeste, Lapa, São Miguel, Santo Amaro and Nossa Senhora do Ó) to the Basic Health Units, the Technical Technical Supervisions and Health Coordinating Offices

Programa Municipal Controle Tuberculose e Assistência Laboratorial – Orientações para coleta e envio de amostras biológicas para realização do teste de liberação de interferon-gama (IFN-γ), do inglês interferon-gama release assay (IGRA)
Municipal Tuberculosis Control Tuberculosis and Laboratory Assistance - Guidelines for collecting and sending biological samples for the for the interferon-gamma (IFN-γ) release assay (IGRA). interferon-gamma release assay (IGRA)

Potencial inibitório do ácido elágico sobre a formação do complexo Keap1-Nrf2: implicações terapêuticas em doenças crônico-degenerativas
Inhibitory potential of ellagic acid on the formation of the keap1-Nrf2 complex: Therapeutical implications in chronic-degenerative diseases

J. Health Sci. Inst; 41 (3), 2023
Objetivos – Avaliar o potencial inibitório do ácido elágico sobre as interações do complexo Keap1-Nrf2, com o intuito de esclarecer um dos eventuais mecanismos associado à atividade antioxidante do ácido elágico. Métodos – Foram empregadas simulações de docagem molecular para prever o modo...

Moderate Toxicity of Potential Boron-containing Therapeutic, Dipotassium-trioxohydroxytetrafl uorotriborate - K2 (B3 O3 F4 OH) in Rats and Mice

Abstract Biological activity of boron-containing compounds (BCCs) has been well-known. Growing interest and numerous applications for BCCs have been reported. Boron and boron-containing acids show low acute toxicity in mammals but data on halogenated boroxine (HB) - dipotassium-trioxohydroxytetrafluorotr...

Preformulation studies for the development of a microemulsion formulation from Ambrosia peruviana All, with anti-inflammatory effect

Abstract Natural products are considered an important source of the therapeutic arsenal currently available. Among these alternatives are the seeds of Ambrosia peruviana (altamisa), whose extract has shown an anti-inflammatory effect. The main objective of this work was to perform a preformulation study ...

Expenditure of biological drugs for rheumatoid arthritis treatment in the Brazilian public health system

ABSTRACT OBJECTIVE This work aims to analyze the quantity and expenses related to biological drugs used for the treatment of rheumatoid arthritis (RA) in outpatient public care within the Brazilian Unified Health System (SUS). METHODS It is a cross-sectional descriptive study based on secondary data ...