A doença de Chagas é causada pelo Trypanosoma cruzi, e atualmente, acomete entre 6 a 7 milhões de pessoas em todo o mundo. A quimioterapia disponível para seu o tratamento se baseia apenas em dois fármacos, nifurtimox e benznidazol, com mais de 50 anos de descoberto. Estes fármacos apresentam efic...
Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignant tumors. Ethanol extract of Antrodia cinnamomea (EEA) has been widely studied for its health benefits including anticancer effects. The purpose of this study was to assess the effects of EEA on HNSCC. Cell proliferation, tra...
Antrodia/química,
Apoptosis/efectos de los fármacos,
Productos Biológicos/farmacología,
Western Blotting,
Línea Celular Tumoral,
Proliferación Celular/efectos de los fármacos,
Etanol/aislamiento & purificación,
Etanol/farmacología,
Neoplasias Pulmonares/tratamiento farmacológico,
Neoplasias Pulmonares/patología,
Ratones Endogámicos BALB C,
Carcinoma de Células Escamosas de Cabeza y Cuello/tratamiento farmacológico,
Carcinoma de Células Escamosas de Cabeza y Cuello/patología,
Factores de Tiempo
Abstract Natural products have emerged as a rich source of bioactive compounds for adjunctive treatments of many infectious and inflammatory conditions, including periodontitis. Among the monoterpenes with significant biological properties, there is the perillyl alcohol (POH), which can be found in sever...
Antibacterianos/farmacología,
Arginasa/análisis,
Productos Biológicos/farmacología,
Proliferación Celular/efectos de los fármacos,
Citometría de Flujo,
Fusobacterium nucleatum/efectos de los fármacos,
Fusobacterium nucleatum/crecimiento & desarrollo,
Expresión Génica,
Lipopolisacáridos/farmacología,
Macrófagos/efectos de los fármacos,
Macrófagos/metabolismo,
Pruebas de Sensibilidad Microbiana,
Monoterpenos/farmacología,
Porphyromonas/efectos de los fármacos,
Porphyromonas/crecimiento & desarrollo,
Células RAW 264.7,
Especies Reactivas de Oxígeno/análisis,
Especies Reactivas de Oxígeno/metabolismo,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Reproducibilidad de los Resultados,
Factores de Tiempo,
Factor de Necrosis Tumoral alfa/análisis
Abstract Synadenium grantii is a Euphorbiaceae plant commonly found in Brazil, known as Janaúba or Leitosinha, whose latex is traditionally used for several purposes. However, it is not known whether the nematicidal action of this plant latex occurs due to the action of proteases. The present work aims ...
Nascimento, Thatyanne Gradowski do;
Vieira, Priscilla Santos;
Cogo, Sheron Campos;
Dias-Netipanyj, Marcela Ferreira;
França Junior, Nilton de;
Câmara, Diana Aparecida Dias;
Porcacchia, Allan Saj;
Mendonça, Ronaldo Zucatelli;
Moreno-Amaral, Andréa Novais;
Sá Junior, Paulo Luiz de;
Simons, Simone Michaela;
Zischler, Luciana;
Elifio-Esposito, Selene.
Abstract The antitumor properties of ticks salivary gland extracts or recombinant proteins have been reported recently, but little is known about the antitumor properties of the secreted components of saliva. The goal of this study was to investigate the in vitro effect of the saliva of the hard tick Am...
Antineoplásicos/aislamiento & purificación,
Antineoplásicos/farmacología,
Apoptosis/efectos de los fármacos,
Proteínas de Artrópodos/aislamiento & purificación,
Proteínas de Artrópodos/farmacología,
Productos Biológicos/aislamiento & purificación,
Productos Biológicos/farmacología,
Línea Celular Tumoral,
Supervivencia Celular/efectos de los fármacos,
Citoesqueleto/efectos de los fármacos,
Ixodidae/química,
Neuroblastoma/patología,
Saliva/química
Cell cycle control genes are frequently mutated in cancer cells, which usually display higher rates of proliferation than normal cells. Dysregulated mitosis leads to genomic instability, which contributes to tumor progression and aggressiveness. Many drugs that disrupt mitosis have been studied because t...
BACKGROUND: The marine environment is a rich source of bioactive natural products. Many of the marine bioactive compounds have been derived successfully from molluscs. Euchelus asper is a marine mollusc which is commonly found in the intertidal rocky regions of the Mumbai coast. The present study was foc...
Graziola, Fabiana;
Candido, Thalita Marcílio;
Oliveira, Camila Areias de;
Peres, Daniela D'Almeida;
Issa, Michele Georges;
Mota, Joana;
Rosado, Catarina;
Consiglieri, Vladi Olga;
Kaneko, Telma Mary;
Velasco, Maria Valéria Robles;
Baby, André Rolim.
ABSTRACT Glutaraldehyde (GTA) has been extensively used as a gelatin crosslinking agent, however, new natural ones have been suggested as more biocompatible. Polyphenols are possible candidates and the flavonols, such as rutin (RUT), also exhibit potential synergism with sunscreens and antioxidant agents...
ABSTRACT PURPOSE: To investigate the potential efficacy of beractant (Survanta(r)) and Seprafilm(r) on the prevention of postoperative adhesions. METHODS: Forty Wistar-albino female rats were used. The rats were randomly allocated into four groups of 10 rats each as control group (CG), beractant group ...
Productos Biológicos/farmacología,
Enfermedades del Ciego/prevención & control,
Ciego/efectos de los fármacos,
Ácido Hialurónico/farmacología,
Ciego/patología,
Ciego/cirugía,
Quimioterapia Combinada/métodos,
Fibrosis,
Inflamación/patología,
Inflamación/prevención & control,
Modelos Animales,
Peritoneo/efectos de los fármacos,
Peritoneo/patología,
Cuidados Posoperatorios/instrumentación,
Distribución Aleatoria,
Ratas Wistar,
Adherencias Tisulares/patología,
Adherencias Tisulares/prevención & control
