SUMMARY: Resveratrol (RES) and quercetine (QRC), is a promising agent relevant for both cancer chemoprevention and treatment via several signaling pathways, involved in their anticancer activity related to its chemotherapeutic potential, associated with the induction of ROS generation in cancer cells, le...
Cancer cells
modify lipid metabolism to proliferate,
Passiflora edulis
(
P. edulis
) fruit juice
(ZuFru) has antitumor activity, but whether a mechanism is through modulation of cell lipids is unknown.
T
o establish if ZuFru modifies cholesterol and triglycerides in SW480
and SW620...
Passiflora/química,
Extractos Vegetales/administración & dosificación,
Anticarcinógenos,
Jugos de Frutas y Vegetales/análisis,
Neoplasias Colorrectales/tratamiento farmacológico,
Proliferación Celular/efectos de los fármacos,
Colesterol,
Triglicéridos,
Línea Celular Tumoral/efectos de los fármacos,
Extractos Vegetales/química,
Fenoles/análisis,
Flavonoides/análisis,
Antioxidantes,
Supervivencia Celular/efectos de los fármacos,
Polisacáridos/análisis
SUMMARY: The objective of this study was to investigate the therapeutic wound healing potential and molecular mechanisms of shikonin as small molecules in vitro. A mouse burn model was used to explore the potential therapeutic effect of shikonin; we traced proliferating cells in vivo to locate the active...
Cicatrización de Heridas/efectos de los fármacos,
Quemaduras/tratamiento farmacológico,
Piel,
Modelos Animales de Enfermedad,
Técnicas In Vitro,
Fibroblastos,
Fosfatidilinositol 3-Quinasas,
Proteínas Proto-Oncogénicas c-akt,
Naftoquinonas/administración & dosificación,
Ratones Endogámicos C57BL,
Naftoquinonas/farmacología,
Proliferación Celular/efectos de los fármacos
Triterpenes are very important secondary metabolites with wide structural diversity and
significant role in pharmacy and medicine.
In the present research, a comparative study of
pharamacological activities of the triterpene fractions obtained from several pla...
SUMMARY: Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is highly expressed in various types of cancers including breast cancer. However, the role of AhR with its endogenous ligand 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE) on the progression...
Indoles/administración & dosificación,
Tiazoles/administración & dosificación,
Receptores de Hidrocarburo de Aril/efectos de los fármacos,
Neoplasias de la Mama/patología,
Indoles/farmacología,
Tiazoles/farmacología,
Receptores de Estrógenos,
Inmunohistoquímica,
Proliferación Celular/efectos de los fármacos,
Citometría de Flujo,
Ensayos de Migración Celular,
Western Blotting,
Línea Celular Tumoral/efectos de los fármacos,
Citocromo P-450 CYP1A1/genética,
Citocromo P-450 CYP1B1/genética
Pavón, Alequis;
Corsini, Gino;
Orellana, Paz;
Calisto, Nancy;
Navarro, Laura;
Wiese, Guillermo;
Cortés-Cortés, Piedad;
Gidekel, Manuel;
Gutierrez-Moraga, Ana;
Salazar, Lorena.
SUMMARY: Cancer is the second leading cause of death in the world and colorectal cancer is the only cancer that has shown a sustained increase in mortality in the last decade. In the search for new chemotherapeutic agents against cancer, extremophilic microorganisms have shown to be a potential source to...
Microbiología del Suelo,
Regiones Antárticas,
Bacillus/fisiología,
Bacillus/aislamiento & purificación,
Bacillus/genética,
Proliferación Celular/efectos de los fármacos,
Neoplasias Colorrectales/tratamiento farmacológico,
Línea Celular Tumoral/efectos de los fármacos,
Supervivencia Celular/efectos de los fármacos,
ARN Ribosómico 16S,
Fenotipo,
Genotipo,
Técnicas In Vitro,
Adenocarcinoma/tratamiento farmacológico,
Reacción en Cadena de la Polimerasa
Methanol extract of Muntingia calabura L. leaf (MEMCL) has been shown to exert the antiproliferative activity against the HT-29 (human colon adenocarcinoma) cell line. To further investigate on the medicinal potential of this plant, MEMCL was sequentially partit...
In this study, it was aimed to determine the antioxidant and anticancer activities of Sideritis perfoliata methanolic extract (SPE) on cervical cancer cells (HeLa). Different doses (25, 50,100 and 200 μg/mL) of SPE were used to determine proliferation of HeLa cells by 3-[4,5-dimethylthiazol-2-yl]-2,5-di...
Neoplasias del Cuello Uterino,
Sideritis/química,
Proliferación Celular/efectos de los fármacos,
Apoptosis/efectos de los fármacos,
Antioxidantes/administración & dosificación,
Extractos Vegetales/administración & dosificación,
Antineoplásicos,
Interleucina-8/análisis,
Interleucina-6/análisis,
Extractos Vegetales/química,
Antioxidantes/química,
Fenoles/análisis,
Supervivencia Celular,
Cromatografía de Gases y Espectrometría de Masas
SUMMARY: Cancer known as a malignant tumor, is a class of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. The Ehrlich tumor is a mammary adenocarcinoma of mice developed in solid and ascitic forms. This study was aimed to investigate the effects ...
Carcinoma de Ehrlich/tratamiento farmacológico,
Paclitaxel/administración & dosificación,
Antineoplásicos Fitogénicos/administración & dosificación,
Paclitaxel/farmacología,
Antineoplásicos Fitogénicos/farmacología,
Netrina-1/antagonistas & inhibidores,
Factor VIII,
Apoptosis,
Inmunohistoquímica,
Ratones Endogámicos BALB C,
Neovascularización Patológica,
Densidad Microvascular/efectos de los fármacos,
Proliferación Celular/efectos de los fármacos
BACKGROUND: Diosmetin is a bioflavonoid compound naturally abundant in citrus fruits. It is found to perform a variety of activities, while its antitumor property in osteosarcoma, a malignant tumor with unmet clinical treatment, remained unknown. METHODS: Colony formation assay, cell cycle analysis and a...
