Aim: Cyclooxygenase enzymes (COX) catalyze the conversion of arachidonic acid to prostaglandins and thromboxanes during pain and inflammation conditions. These enzymes have also been linked to several other conditions and diseases, and hence, in dentistry, it is crucial to identify the processes that inc...
A erupção pigmentar fixa (EPF) é uma reação cutânea adversa a drogas relativamente comum, envolvendo cerca de 10% de todas as reações de hipersensibilidade a medicamentos (RHM). Envolve uma reação imunológica não imediata, mediada por células T CD8+ sensibilizadas, relacionada ao mecanismo d...
Abstract Objectives: Infection, inflammation and bone resorption are closely related events in apical periodontitis development. Therefore, we sought to investigate the role of cyclooxygenase (COX) in osteoclastogenesis and bone metabolism signaling in periapical bone tissue after bacterial lipopolysacc...
Antiinflamatorios no Esteroideos/farmacología,
Resorción Ósea/metabolismo,
Celecoxib/farmacología,
Ciclooxigenasa 2/análisis,
Inhibidores de la Ciclooxigenasa/farmacología,
Cavidad Pulpar/metabolismo,
Escherichia coli/metabolismo,
Expresión Génica,
Indometacina/farmacología,
Lipopolisacáridos/análisis,
Lipopolisacáridos/farmacología,
Ratones Endogámicos C57BL,
Osteogénesis/efectos de los fármacos,
Osteogénesis/fisiología,
Tejido Periapical/efectos de los fármacos,
Tejido Periapical/metabolismo,
Prostaglandina-Endoperóxido Sintasas/análisis,
Prostaglandina-Endoperóxido Sintasas/efectos de los fármacos,
Prostaglandina-Endoperóxido Sintasas/fisiología,
Receptores de Prostaglandina E/análisis,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Factores de Tiempo,
Regulación hacia Arriba
Eicosanoids are 20-carbon bioactive lipids derived from the metabolism of polyunsaturated fatty acids, which can modulate various biological processes including cell proliferation, adhesion and migration, angiogenesis, vascular permeability and inflammatory responses. In recent years, studies have shown ...
Ácido Araquidónico/metabolismo,
Eicosanoides/farmacología,
Eicosanoides/fisiología,
Ácidos Grasos Insaturados/metabolismo,
Inflamación/enzimología,
Neoplasias/tratamiento farmacológico,
Neoplasias/enzimología,
Neoplasias/patología,
Neovascularización Patológica/etiología,
Prostaglandina-Endoperóxido Sintasas/metabolismo,
Prostaglandinas
Abstract Objective: Periodontitis is associated with endothelial dysfunction, which is clinically characterized by a reduction in endothelium-dependent relaxation. However, we have previously shown that impairment in endothelium-dependent relaxation is transient. Therefore, we evaluated which mediators ...
Acetilcolina/farmacología,
Pérdida de Hueso Alveolar/metabolismo,
Pérdida de Hueso Alveolar/fisiopatología,
Presión Arterial/efectos de los fármacos,
Presión Arterial/fisiología,
Proteína C-Reactiva/análisis,
Inhibidores de la Ciclooxigenasa/farmacología,
Ligadura,
NG-Nitroarginina Metil Éster/farmacología,
Óxido Nítrico/metabolismo,
Nitroprusiato/farmacología,
Periodontitis/metabolismo,
Periodontitis/fisiopatología,
Peroxidasa/análisis,
Bloqueadores de los Canales de Potasio/farmacología,
Canales de Potasio/efectos de los fármacos,
Canales de Potasio/metabolismo,
Prostaglandina-Endoperóxido Sintasas/efectos de los fármacos,
Prostaglandina-Endoperóxido Sintasas/metabolismo,
Distribución Aleatoria,
Ratas Wistar,
Factores de Tiempo,
Vasodilatación/efectos de los fármacos,
Vasodilatación/fisiología,
Vasodilatadores/farmacología
Abstract Previous studies performed in marine fish (I. conceptionis and G. laevifrons) showed that indomethacin blocked arterial contraction mediated by acetylcholine (ACh). The objective of this study was to determine if contraction induced by acetylcholine is mediated by the cyclooxygenase pathway in s...
Reações de hipersensibilidade a medicamentos (RHM) podem induzir manifestações clínicas heterogêneas, desde leves até graves. São classificadas em imunológicas ou alérgicas quando mediadas por anticorpos ou linfócitos T, e não imunológicas quando decorrentes de efeitos farmacológicos da dro...
The effects of the cyclooxygenase (COX)-2 selective inhibitor, valdecoxib, on blood coagulation parameters were evaluated, along with aspirin in male Wistar rats. Groups of animals were administered a daily oral dose of 10 mg/kg rat of valdecoxib, 100 mg/kg rat of aspirin and the vehicle alone during 4 w...
Prostaglandina-Endoperóxido Sintasas,
Aspirina,
Coagulación Sanguínea,
Recuento de Plaquetas,
Dosificación,
Hemostáticos,
Ratas Wistar,
Tiempo de Protrombina,
Tiempo de Tromboplastina Parcial,
Fibrinógeno,
Cromatografía Liquida,
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