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Pathophysiological aspects of nephropathy caused by non-steroidal anti-inflammatory drugs

Lucas, Guillherme Nobre Cavalcanti; Leitão, Ana Carla Carneiro; Alencar, Renan Lima; Xavier, Rosa Malena Fagundes; Daher, Elizabeth De Francesco; Silva Junior, Geraldo Bezerra da.
J. bras. nefrol; 41 (1), 2019
Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used medications associated with nephrotoxicity, especially when used chronically. Factors such as advanced age and comorbidities, which in themselves already lead to a decrease in glomerular filtration rate, increase the risk of NSAID-...
Lesión Renal Aguda/inducido químicamente, Lesión Renal Aguda/fisiopatología, Antiinflamatorios no Esteroideos/efectos adversos, Antiinflamatorios no Esteroideos/metabolismo, Inhibidores de la Ciclooxigenasa/efectos adversos, Inhibidores de la Ciclooxigenasa/metabolismo, Nefritis Intersticial/inducido químicamente, Nefritis Intersticial/fisiopatología, Prostaglandinas E/metabolismo, Proteinuria/inducido químicamente, Insuficiencia Renal Crónica/inducido químicamente, Insuficiencia Renal Crónica/fisiopatología, Factores de Riesgo
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Inhibitory effects on the production of inflammatory mediators and reactive oxygen species by Mori folium in lipopolysaccharide-stimulated macrophages and zebrafish

KWON, DA HYE; JEONG, JIN WOO; CHOI, EUN OK; LEE, HYE WON; LEE, KI WON; KIM, KI YOUNG; KIM, SUNG GOO; HONG, SU HYUN; KIM, GI-YOUNG; PARK, CHEOL; HWANG, HYE-JIN; SON, CHANG-GUE; CHOI, YUNG HYUN.
An. acad. bras. ciênc; 89 (1,supl), 2017
ABSTRACT Mori folium, the leaf of Morus alba L. (Moraceae), has been traditionally used for various medicinal purposes from ancient times to the present. In this study, we examined the effects of water extract of Mori folium (WEMF) on the production of inflammatory mediators, such as nitric oxide (NO) an...
Expresión Génica, Genes Reguladores, Mediadores de Inflamación/antagonistas & inhibidores, Mediadores de Inflamación/metabolismo, Lipopolisacáridos, Macrófagos/efectos de los fármacos, Macrófagos/metabolismo, Morus/química, Óxido Nítrico/metabolismo, Extractos Vegetales/farmacología, Prostaglandinas E/metabolismo, Células RAW 264.7, Especies Reactivas de Oxígeno/antagonistas & inhibidores, Pez Cebra
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