LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Novel mechanisms underlying anti-polycystic ovary like syndrome effects of electroacupuncture in rats: suppressing SREBP1 to mitigate insulin resistance, mitochondrial dysfunction and oxidative stress

BACKGROUND: Acupuncture, a therapy of traditional Chinese medicine, is confirmed to exert the therapeutic action on polycystic ovary syndrome (PCOS). However, the detailed therapeutic mechanisms of acupuncture in PCOS remain ambiguous. In this study, we further investigated whether electroacupuncture (EA...

RASAL1 induces to downregulate the SCD1, leading to suppression of cell proliferation in colon cancer via LXRα/SREBP1c pathway

Wang, Guangchuan; Li, Zhen; Li, Xiao; Zhang, Chunqing; Peng, Lipan.

Biol. Res; 52 (), 2019

BACKGROUND: Recent studies have confirmed that RASAL1 has an antitumor effect in many cancers, but its functional role and the molecular mechanism underlying in colon cancer has not been investigated. RESULTS: We collected human colon cancer tissues and adjacent non-tumor tissues, human colon cancer cell...

Proliferación Celular/fisiología, Neoplasias del Colon/patología, Proteínas Activadoras de GTPasa/metabolismo, Receptores X del Hígado/metabolismo, Estearoil-CoA Desaturasa/metabolismo, Proteína 1 de Unión a los Elementos Reguladores de Esteroles/metabolismo, Proteínas Activadoras de GTPasa/genética, Receptores X del Hígado/genética, Estearoil-CoA Desaturasa/genética, Proteína 1 de Unión a los Elementos Reguladores de Esteroles/genética, Línea Celular Tumoral, Regulación hacia Abajo

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