LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

rs7903146 mutation of Type 2 diabetes mellitus-related gene TCF7L2 is not associated with polycystic ovary syndrome in a cohort of Turkey

Taşkin, Emre; Eroğlu, Semra.

Rev. Assoc. Med. Bras. (1992); 67 (8), 2021

SUMMARY OBJECTIVE The aim of this study was to investigate whether TCF7L2 gene mutation rs7903146 is in association with polycystic ovary syndrome (PCOS). METHODS A total of 44 PCOS and 48 control participants were recruited for this study. After DNA extraction from peripheral blood, quantitative PCR m...

Estudios de Casos y Controles, Diabetes Mellitus Tipo 2, Frecuencia de los Genes, Predisposición Genética a la Enfermedad, Genotipo, Mutación, Síndrome del Ovario Poliquístico/genética, Polimorfismo de Nucleótido Simple, Proteína 2 Similar al Factor de Transcripción 7/genética, Turquía

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Asociación del polimorfismo rs7903146, del gen TCF7L2, con marcadores de adiposidad y metabólicos en población chilena - resultados del estudio GENADIO

Petermann-Rocha, Fanny; Lasserre-Laso, Nicole; Villagrán, Marcelo; Mardones, Lorena; Martínez, María Adela; Leiva, Ana María; Ulloa, Natalia; Celis-Morales, Carlos.

Rev. méd. Chile; 147 (8), 2019

Background: Type 2 diabetes etiology has a strong genetic component. More than 20 genetic variants have been associated with diabetes and other metabolic markers. However, the polymorphism rs7903146 of the TCF7L2 gene has shown the strongest association. Aim: To investigate the association of TCF7L2 (rs...

Adiposidad/genética, Diabetes Mellitus Tipo 2/genética, Polimorfismo de Nucleótido Simple, Proteína 2 Similar al Factor de Transcripción 7/genética, Adiposidad/etnología, Alelos, Antropometría, Glucemia/genética, Chile, Estudios Transversales, Diabetes Mellitus Tipo 2/metabolismo, Frecuencia de los Genes, Estudios de Asociación Genética, Marcadores Genéticos, Genotipo, Modelos Lineales, Estado Nutricional, Valores de Referencia, Factores de Riesgo

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Type 2 diabetes-associated genetic variants of FTO, LEPR, PPARg, and TCF7L2 in gestational diabetes in a Brazilian population

Anghebem-Oliveira, Mauren Isfer; Martins, Bruna Rodrigues; Alberton, Dayane; Ramos, Edneia Amancio de Souza; Picheth, Geraldo; Rego, Fabiane Gomes de Moraes.

Arch. endocrinol. metab. (Online); 61 (3), 2017

ABSTRACT Objective Gestational diabetes mellitus (GDM) is a metabolic disorder that shares pathophysiologic features with type 2 diabetes mellitus. The aim of this study was to investigate the association of the polymorphisms fat mass and obesity-associated (FTO) rs1421085, leptin receptor (LEPR) rs113...

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Design of an allele-specific PCR assay to genotype the rs12255372 SNP in a pilot study of association between common TCF7L2 polymorphisms and type 2 diabetes in Venezuelans

Moran, Yeinmy; Labrador, Luis; Camargo, María Eugenia; Fernández, David; Chiurillo, Miguel Angel.

Arch. endocrinol. metab. (Online); 60 (3), 2016

Objective The global burden of diabetes mellitus will impact strongly American countries in the coming decades. Type 2 diabetes mellitus (T2DM) is a multifactorial disease and the basis for its genetic susceptibility remains not fully understood. Different population studies have demonstrated that varian...

Alelos, Estudios de Casos y Controles, Diabetes Mellitus Tipo 2/etnología, Diabetes Mellitus Tipo 2/genética, Frecuencia de los Genes, Estudios de Asociación Genética, Marcadores Genéticos, Técnicas de Genotipaje/métodos, Proyectos Piloto, Reacción en Cadena de la Polimerasa/métodos, Polimorfismo de Longitud del Fragmento de Restricción, Polimorfismo de Nucleótido Simple/genética, Reproducibilidad de los Resultados, Factores de Riesgo, Proteína 2 Similar al Factor de Transcripción 7/genética, Venezuela

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