Results: 6

Associations of high-mobility group box 1 and receptor for advanced glycation end products with acute lung injury in patient with acute aortic dissection

Zeng, Zhaofan; Zhang, Kun; Cai, Junhong; Wu, Hongfei; Yue, Jie.

Rev. Assoc. Med. Bras. (1992, Impr.); 67 (9), 2021

SUMMARY OBJECTIVE: To investigate the associations of high-mobility group box 1 and its specific receptor, receptor for advanced glycation end products with acute lung injury in patients with acute aortic dissection. METHODS: A total of 96 acute aortic dissection patients were divided into acute aortic...

Lesión Pulmonar Aguda/etiología, Disección Aórtica, Productos Finales de Glicación Avanzada, Proteína HMGB1/metabolismo, Receptor para Productos Finales de Glicación Avanzada/metabolismo

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Upregulation of miR-129-5p increases the sensitivity to Taxol through inhibiting HMGB1-mediated cell autophagy in breast cancer MCF-7 cells

Shi, Ying; Gong, Weihua; Lu, Lu; Wang, Yunfeng; Ren, Jingjing.

Braz. j. med. biol. res; 52 (11), 2019

Although Taxol has improved the survival of cancer patients as a first-line chemotherapeutic agent, an increasing number of patients develop resistance to Taxol after prolonged treatment. The potential mechanisms of cancer cell resistance to Taxol are not completely clear. It has been reported that micro...

Antineoplásicos Fitogénicos/metabolismo, Antineoplásicos Fitogénicos/uso terapéutico, Apoptosis/genética, Autofagia/genética, Neoplasias de la Mama/tratamiento farmacológico, Neoplasias de la Mama/genética, Neoplasias de la Mama/metabolismo, Resistencia a Antineoplásicos/genética, Regulación Neoplásica de la Expresión Génica/genética, Proteína HMGB1/genética, Proteína HMGB1/metabolismo, Células MCF-7/metabolismo, MicroARNs/genética, MicroARNs/metabolismo, Paclitaxel/metabolismo, Paclitaxel/uso terapéutico, Regulación hacia Arriba/genética

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Saquinavir plus methylprednisolone ameliorates experimental acute lung injury

Zhang, Guanghua; Zhang, Xue; Huang, Haidi; Ji, Yunxia; Li, Defang; Jiang, Wanglin.

Braz. j. med. biol. res; 51 (10), 2018

Glucocorticoid insensitivity is an important barrier to the treatment of several inflammatory diseases, including acute lung injury (ALI). Saquinavir (SQV) is an inhibitor of the human immunodeficiency virus protease, and the therapeutic effects of SQV in ALI accompanied with glucocorticoid insensitivity...

Lesión Pulmonar Aguda/inducido químicamente, Lesión Pulmonar Aguda/tratamiento farmacológico, Antígenos CD/efectos de los fármacos, Antígenos CD/metabolismo, Cadherinas/efectos de los fármacos, Cadherinas/metabolismo, Modelos Animales de Enfermedad, Proteína HMGB1/efectos de los fármacos, Proteína HMGB1/metabolismo, Lipopolisacáridos, Metilprednisolona/administración & dosificación, Ratas Sprague-Dawley, Saquinavir/administración & dosificación, Transducción de Señal/efectos de los fármacos, Receptor Toll-Like 4/efectos de los fármacos, Receptor Toll-Like 4/metabolismo

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Strong renal expression of heat shock protein 70, high mobility group box 1, inducible nitric oxide synthase, and nitrotyrosine in mice model of severe malaria

Fitri, Loeki Enggar; Rosmarwati, Ervina; Rizky, Yesita; Budiarti, Niniek; Samsu, Nur; Mintaroem, Karyono.

Rev. Soc. Bras. Med. Trop; 50 (4), 2017

Abstract INTRODUCTION Renal damage is a consequence of severe malaria, and is generally caused by sequestration of Plasmodium falciparum -infected erythrocytes in the renal microcirculation, which leads to obstruction, hypoxia, and ischemia. This triggers high mobility group box 1 (HMGB1) to send a dang...

Lesión Renal Aguda/parasitología, Modelos Animales de Enfermedad, Proteína HMGB1/metabolismo, Proteínas HSP70 de Choque Térmico/metabolismo, Malaria/complicaciones, Malaria/metabolismo, Ratones, Ratones Endogámicos C57BL, Óxido Nítrico Sintasa de Tipo II/metabolismo, Índice de Severidad de la Enfermedad, Tirosina/antagonistas & inhibidores, Tirosina/metabolismo

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Metabotropic glutamate receptor 5 may be involved in macrophage plasticity

Shanshiashvili, Lali; Tsitsilashvili, Elene; Dabrundashvili, Nino; Kalandadze, Irine; Mikeladze, David.

Biol. Res; 50 (), 2017

Abstract Background Macrophages are a functionally heterogeneous cell population and depending on microenvironments they polarize in two main groups: M1 and M2. Glutamic acid and glutamate receptors may participate in the regulation of macrophage plasticity. To investigate the role of glutamatergic sys...

Plasticidad de la Célula/fisiología, Macrófagos/fisiología, Receptor del Glutamato Metabotropico 5/fisiología, Western Blotting, Células Cultivadas, Ensayo de Inmunoadsorción Enzimática, Galectina 3/análisis, Galectina 3/metabolismo, Ácido Glutámico/análisis, Ácido Glutámico/metabolismo, Proteína HMGB1/análisis, Proteína HMGB1/metabolismo, Interleucina-10/análisis, Interleucina-10/metabolismo, Lipopolisacáridos, Óxido Nítrico/metabolismo, PPAR alfa/análisis, PPAR alfa/metabolismo, Fenotipo, Células RAW 264.7, TransfecciónMétodos

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Allopurinol preconditioning attenuates renal ischemia/reperfusion injury by inhibiting HMGB1 expression in a rat model

Zhou, Jiang-qiao; Qiu, Tao; Zhang, Lu; Chen, Zhong-bao; Wang, Zhi-shun; Ma, Xiao-xiong; Li, Dongyu.

Acta cir. bras; 31 (3), 2016

ABSTRACT PURPOSE: To investigate the potential effects of pretreatment with allopurinol on renal ischemia/reperfusion injury (IRI) in a rat model. METHODS: Twenty four rats were subjected to right kidney uninephrectomy were randomly distributed into the following three groups (n=8): Group A (sham-ope...

Alopurinol/farmacología, Proteína HMGB1/efectos de los fármacos, Precondicionamiento Isquémico/métodos, Riñón/irrigación sanguínea, Sustancias Protectoras/farmacología, Daño por Reperfusión/prevención & control, Apoptosis/efectos de los fármacos, Nitrógeno de la Urea Sanguínea, Modelos Animales de Enfermedad, Proteína HMGB1/metabolismo, Inflamación/metabolismo, Riñón/patología, Peroxidasa/metabolismo, Distribución Aleatoria, Ratas Sprague-Dawley, Daño por Reperfusión/metabolismo, Superóxido Dismutasa/efectos de los fármacos

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