Low concentrations of doxycycline attenuates FasL-induced apoptosis in HeLa cells
Biol. Res; 48 (), 2015
BACKGROUND: Doxycycline (DC) has been shown to possess non-antibiotic properties including Fas/Fas Ligand (FasL)-mediated apoptosis against several tumor types in the concentration range of 10-40 µg/mL. However, the effect of DC in apoptotic signaling at much low concentrations was not studied. METHODS:...
Apoptosis/efectos de los fármacos, Caspasas/efectos de los fármacos, Doxiciclina/administración & dosificación, Proteína Ligando Fas/efectos de los fármacos, Doxiciclina/farmacología, Western Blotting, Relación Dosis-Respuesta a Droga, Activación Enzimática, Citometría de Flujo, Células HeLa, Células 3T3 NIH