LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Evaluation of miR-15a, miR-16-1, ZAP-70, Ang-2, and Bcl-2 as potential prognostic biomarkers in chronic lymphocytic leukemia

Braga, Tatiane Vieira; Evangelista, Fernanda Cristina Gontijo; Santiago, Marie Gabriele; Ferrão, Aline Lúcia Menezes; Almeida, Tamara Dauare de; Barbosa, Bárbara Lima da Fonseca; Araujo, Sergio Schusterschitz da Silva; Ribeiro, Glaciano Nogueira; Carvalho, Maria das Graças; Sabino, Adriano de Paula.

Braz. J. Pharm. Sci. (Online); 58 (), 2022

Chronic lymphocytic leukemia (CLL) is a blood cancer characterized by the accumulation of clonal B-lymphocytes. This study evaluated the mRNA gene expression of miR-15a, miR-16- 1, ZAP-70, and Ang-2 by qPCR, as well as the plasma levels of Bcl-2 by Elisa immunoassay, in CLL patients and healthy controls....

Proteína Tirosina Quinasa ZAP-70/análisis, Leucemia Linfocítica Crónica de Células B/patología, Biomarcadores/análisis, Ensayo de Inmunoadsorción Enzimática/instrumentación, Apoptosis, Expresión Génica, Pacientes

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