Ketamine ameliorates hypoxia-induced endothelial injury in human umbilical vein endothelial cells
Clinics; 75 (), 2020
OBJECTIVES: Hypoxia leads to endothelial cell inflammation, apoptosis, and damage, which plays an important role in the complications associated with ischemic cardiovascular disease. As an oxidoreductase, p66Shc plays an important role in the regulation of reactive oxygen species (ROS) production and apo...
Apoptosis/efectos de los fármacos, Supervivencia Celular, Células Endoteliales de la Vena Umbilical Humana/efectos de los fármacos, Células Endoteliales de la Vena Umbilical Humana/metabolismo, Hipoxia, Ketamina/farmacología, Estrés Oxidativo, Especies Reactivas de Oxígeno/metabolismo, Proteína Transformadora 1 que Contiene Dominios de Homología 2 de Src, Venas Umbilicales