SUMMARY: Intervertebral disc degeneration (IVDD) is induced by nucleus pulposus (NP) dysfunction as a result of massive loss of NP cells. It has been reported that the acidic microenvironment of the intervertebral disc (IVD) can induce NP cell pyroptosis, and that up-regulation of periostin (POSTN) expre...
Ácidos/química,
Ambiente,
Degeneración del Disco Intervertebral,
Núcleo Pulposo/fisiopatología,
Moléculas de Adhesión Celular/metabolismo,
Núcleo Pulposo/citología,
Proteína con Dominio Pirina 3 de la Familia NLR,
Ratas Sprague-Dawley,
Moléculas de Adhesión Celular/genética,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Western Blotting,
Ensayo de Inmunoadsorción Enzimática,
Supervivencia Celular,
d0123330
Taha, Medhat;
Ibrahim, Mohie Mahmoud;
Elazab, Sara T;
Badawy, Alaa. M;
Abdelsalam, Ramy A;
Saati, Abdullah A;
Qusty, Naeem F;
Babateen, Omar;
Abdelbagi, Omer;
Hendawy, M.
SUMMARY: One of the reasons for acute kidney damage is renal ischemia. Nevertheless, there are limited protective and therapeutic approaches for this problem. Diacerein is an anti-inflammatory drug characterized by numerous biological activities. We aimed to determine the ameliorative impact of diacerein...
Antraquinonas/administración & dosificación,
Antiinflamatorios/administración & dosificación,
Daño por Reperfusión/tratamiento farmacológico,
Antraquinonas/inmunología,
Células Dendríticas/efectos de los fármacos,
Apoptosis/efectos de los fármacos,
Enfermedades Renales/tratamiento farmacológico,
Daño por Reperfusión/inmunología,
Enfermedades Renales/inmunología,
Inyecciones Intraperitoneales,
FN-kappa B/metabolismo,
Receptor Toll-Like 4/metabolismo,
Transducción de Señal,
Estrés Oxidativo,
Inflamación,
Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo,
Interleucina-1beta/metabolismo,
Citometría de Flujo,
d0201690,
d0200110
Purpose: Myocardial ischemia/reperfusion injury (MIRI) leads to myocardial tissue necrosis, which will increase the size of myocardial infarction. The study examined the protective effect and mechanism of the Guanxin Danshen formula (GXDSF) on MIRI in rats. Methods: MIRI model was performed in rats; rat ...
Purpose:
Abnormal activation of NOD-like receptor protein 3 (NLRP3) inflammasome can lead to the occurrence and progression of acute pancreatitis. This study investigated the protective effect of MCC950 on pancreatitis mice.
Methods:
Eighteen mice were randomly divided into control group, severe acute p...
Purpose:
Tanshinone IIA is a well-known lipophilic active constituent refined from traditional Chinese medicines, danshen. It has been previously demonstrated to possess various biological properties, including anti-inflammatory, antioxidant, promoting angiogenesis effect and so on. However, the mechanis...
ABSTRACT Purpose: Diabetic retinopathy is currently considered a chronic inflammatory disease involving NOD-like receptor family pyrin domain containing 3 inflammasome activation and retinal microglial pyroptosis. In this study, we aimed to investigate whether NOD-like receptor family pyrin domain conta...
Nuestro grupo ha reportado que la proteína Tmem176b es un canal/transportador iónico intracelular fuertemente expresado en células dendríticas (DCs), que bloquea la respuesta inmune anti-tumoral. Identificamos al compuesto BayK8644 como un inhibidor de Tmem176b. BayK8644 promueve el control tumoral e...
ABSTRACT Purpose: To delve into the influence of paeoniflorin (PA) on abating primary biliary cholangitis (PBC)-induced liver fibrosis and its causative role. Methods: Our team allocated the mice to control group, PA group, PBC group and PBC+PA group. We recorded the weight change of mice in each group...
Mendes, Ana Luisa Gomes;
Joaquim, Heloísa Di Matteo;
Zamae, Mara Inês Stefanini;
Assis, Ramon Meira;
Peixoto, Jéssica Renata de Moura;
de Araújo, Margarida Maria Gomes;
Guedes, Antônio Carlos Martins;
Oliveira, Edward José;
Magalhães, Vanessa Peruhype;
Pascoal-Xavier, Marcelo Antônio.
BACKGROUND Leprosy is an infectious-contagious disease caused by Mycobacterium leprae that remain endemic in 105 countries. This neglected disease has a wide range of clinical and histopathological manifestations that are related to the host inflammatory and immune responses. More recently, the inflamma...
Acne is a kind of common, chronic skin condition caused by the inflammation of the sebaceous glands in hair follicles. Recent studies have demonstrated that baicalin (BA) possesses potential anti-inflammatory properties. In this study, we evaluated the anti-inflammatory activity of BA in vitro and in viv...
Dermatitis/tratamiento farmacológico,
Flavonoides,
Inflamasomas,
Inflamación/inducido químicamente,
Inflamación/tratamiento farmacológico,
Interleucina-1beta/metabolismo,
Sistema de Señalización de MAP Quinasas,
FN-kappa B/metabolismo,
Proteína con Dominio Pirina 3 de la Familia NLR,
Propionibacterium acnes/metabolismo,
Ratas Sprague-Dawley,
Transducción de Señal
