Results: 6

Diacerein mitigates renal ischemia/reperfusion injury via inhibition of renal inflammation, dendritic cells maturation and apoptosis: the role of TLR4/NF-kB/NLRP3/IL-1beta signaling pathway

Taha, Medhat; Ibrahim, Mohie Mahmoud; Elazab, Sara T; Badawy, Alaa. M; Abdelsalam, Ramy A; Saati, Abdullah A; Qusty, Naeem F; Babateen, Omar; Abdelbagi, Omer; Hendawy, M.

Int. j. morphol; 41 (2), 2023

SUMMARY: One of the reasons for acute kidney damage is renal ischemia. Nevertheless, there are limited protective and therapeutic approaches for this problem. Diacerein is an anti-inflammatory drug characterized by numerous biological activities. We aimed to determine the ameliorative impact of diacerein...

Antraquinonas/administración & dosificación, Antiinflamatorios/administración & dosificación, Daño por Reperfusión/tratamiento farmacológico, Antraquinonas/inmunología, Células Dendríticas/efectos de los fármacos, Apoptosis/efectos de los fármacos, Enfermedades Renales/tratamiento farmacológico, Daño por Reperfusión/inmunología, Enfermedades Renales/inmunología, Inyecciones Intraperitoneales, FN-kappa B/metabolismo, Receptor Toll-Like 4/metabolismo, Transducción de Señal, Estrés Oxidativo, Inflamación, Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo, Interleucina-1beta/metabolismo, Citometría de Flujo, d0201690, d0200110

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Paeoniflorin mitigates PBC-induced liver fibrosis by repressing NLRP3 formation

Zhang, Yizhe; Zhang, Shujie; Luo, Xin; Zhao, Han; Xiang, Xiaoxing.

Acta cir. bras; 36 (11), 2021

ABSTRACT Purpose: To delve into the influence of paeoniflorin (PA) on abating primary biliary cholangitis (PBC)-induced liver fibrosis and its causative role. Methods: Our team allocated the mice to control group, PA group, PBC group and PBC+PA group. We recorded the weight change of mice in each group...

Aspartato Aminotransferasas, Glucósidos/farmacología, Hígado/patología, Cirrosis Hepática/tratamiento farmacológico, Cirrosis Hepática/prevención & control, Monoterpenos/farmacología, Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo

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Expression of NLRP3 inflammasome in leprosy indicates immune evasion of Mycobacterium leprae

Mendes, Ana Luisa Gomes; Joaquim, Heloísa Di Matteo; Zamae, Mara Inês Stefanini; Assis, Ramon Meira; Peixoto, Jéssica Renata de Moura; de Araújo, Margarida Maria Gomes; Guedes, Antônio Carlos Martins; Oliveira, Edward José; Magalhães, Vanessa Peruhype; Pascoal-Xavier, Marcelo Antônio.

Mem. Inst. Oswaldo Cruz; 115 (), 2020

BACKGROUND Leprosy is an infectious-contagious disease caused by Mycobacterium leprae that remain endemic in 105 countries. This neglected disease has a wide range of clinical and histopathological manifestations that are related to the host inflammatory and immune responses. More recently, the inflamma...

Estudios Transversales, Evasión Inmune/inmunología, Inmunohistoquímica, Inflamasomas/metabolismo, Lepra/inmunología, Lepra/metabolismo, Lepra/patología, Mycobacterium leprae/inmunología, Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo

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Hypoxia inducible factor-1 (HIF-1α) reduced inflammation in spinal cord injury via miR-380-3p/ NLRP3 by Circ 0001723

Li, Xigong; Lou, Xianfeng; Xu, Sanzhong; Du, Junhua; Wu, Junsong.

Biol. Res; 53 (), 2020

BACKGROUND: Spinal cord injury (SCI) is a severe central nervous system trauma. The present study aimed to evaluate the effect of HIF-1α on inflammation in spinal cord injury (SCI) to uncover the molecular mechanisms of anti-inflammation. RESULTS: HIF-1α was reduced in SCI model rats and HIF-1α activa...

Subunidad alfa del Factor 1 Inducible por Hipoxia/metabolismo, Inflamación/metabolismo, MicroARNs/genética, Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo, ARN Circular/genética, Traumatismos de la Médula Espinal/metabolismo, Citocinas/sangre, Regulación de la Expresión Génica, Ratas Sprague-Dawley

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NLRP3 inflammasome signaling as an early molecular response is negatively controlled by miR-186 in CFA-induced prosopalgia mice

Chen, Ming-lei; Lin, Kang; Lin, Shu-kai.

Braz. j. med. biol. res; 51 (9), 2018

The NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is the most frequently studied in the central nervous system and has been linked to neuropathic pain. In this study, a post-translational mechanism of microRNA (miR)-186 via regulating the expression of NLRP3 in the complete Freu...

Western Blotting, Modelos Animales de Enfermedad, Ensayo de Inmunoadsorción Enzimática, Adyuvante de Freund, Estudios de Asociación Genética, Inflamasomas/análisis, Inflamasomas/fisiología, Interleucina-18/análisis, Interleucina-18/metabolismo, Interleucina-1beta/análisis, Interleucina-1beta/metabolismo, Luciferasas, Ratones Endogámicos C57BL, MicroARNs/farmacología, Análisis por Micromatrices, Proteína con Dominio Pirina 3 de la Familia NLR/análisis, Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo, Distribución Aleatoria, Valores de Referencia, Factores de Tiempo, Neuralgia del Trigémino/tratamiento farmacológico

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Vitamin D3 levels and NLRP3 expression in murine models of obese asthma: association with asthma outcomes

Zhang, J-H; Chen, Y-P; Yang, X; Li, C-Q.

Braz. j. med. biol. res; 51 (1), 2018

Vitamin D (25(OH)D3) is an essential nutrient that plays a role in the immune system. Serum 25(OH)D3 is found to be associated with asthma. However, the role of vitamin D in obese asthma remains unclear. Therefore, we investigated the association between vitamin D levels and asthma outcomes in a murine m...

Asma/metabolismo, Asma/patología, Asma/fisiopatología, Peso Corporal, Líquido del Lavado Bronquioalveolar, Colecalciferol/sangre, Citocinas/análisis, Citocinas/metabolismo, Modelos Animales de Enfermedad, Ensayo de Inmunoadsorción Enzimática, Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo, Obesidad/metabolismo, Obesidad/fisiopatología, Factores de Tiempo

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