LILACS – Literatura Latinoamericana y del Caribe de Ciencias de la Salud

Electroacupuncture inhibits dendritic spine remodeling through the srGAP3-Rac1 signaling pathway in rats with SNL

Previous studies have shown that peripheral nerve injury can lead to abnormal dendritic spine remodeling in spinal dorsal horn neurons. Inhibition of abnormal dendritic spine remodeling can relieve neuropathic pain. Electroacupuncture (EA) has a beneficial effect on the treatment of neuropathic pain, but...

Knockdown of interleukin-10 induces the redistribution of sigma1-receptor and increases the glutamate-dependent NADPH-oxidase activity in mouse brain neurons

Koriauli, S; Natsvlishvili, N; Barbakadze, T; Mikeladze, D.

Biol. Res; 48 (), 2015

BACKGROUND: In the central nervous system, interleukin-10 (IL-10) provides trophic and survival effects directly on neurons, modulates neurite plasticity, and has a pivotal importance in the neuronal regeneration in neurodegenerative and neuroinflammatory conditions. This cytokine is primarily produced b...

Encéfalo/metabolismo, Ácido Glutámico/metabolismo, Interleucina-10/genética, NADPH Oxidasas/metabolismo, Receptores sigma/metabolismo, Membrana Celular/metabolismo, Retículo Endoplásmico/metabolismo, Proteínas de Choque Térmico/metabolismo, Receptores de Inositol 1,4,5-Trifosfato/metabolismo, Neuronas/metabolismo, Especies Reactivas de Oxígeno/análisis, Especies Reactivas de Oxígeno/metabolismo, Receptores de N-Metil-D-Aspartato/metabolismo, Receptores de N-Metil-D-Aspartato/clasificación, Receptores sigma/agonistas, Receptores sigma/clasificación, Proteína de Unión al GTP rac1/metabolismo, Técnicas de Silenciamiento del Gen, Inmunoprecipitación, Ratones Endogámicos C57BL

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